Transdermal delivery of isosorbide 5-mononitrate from a new membrane reservoir and matrix-type patches

被引：5

作者：

Arra, GS ^{[1
]}

Arutla, S ^{[1
]}

Krishna, DR ^{[1
]}

机构：

[1] Kakatiya Univ, Univ Coll Pharmaceut Sci, Drug Metab Lab, Warangal 506009, Andhra Pradesh, India

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1998年 / 24卷 / 05期

关键词：

D O I：

10.3109/03639049809085648

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Isosorbide 5-mononitrate (5-ISMN) has a direct relaxing effect on vascular smooth muscle. In the present study we developed matrix and reservoir-type transdermal patches of 5-ISMN. We investigated the usefulness of a new film-forming material isolated from the roots of Salacia macrosperma to serve as rate-controlling membrane for the reservoir-type patches. Matrix-type patches were formulated using polyvinyl chloride. Permeation studies through rat skin were conducted on both types of patches using Teflon cells. The mean +/- SD flux values from the matrix- and reservoir-type patches were 99.55 +/- 22.89 and 31.82 +/- 8.31 mu g/cm(2) . hr, respectively.

引用

页码：489 / 492

页数：4

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