Evaluation of the acute and sub-acute toxicity of the black caraway seed essential oil in Wistar rats

被引：27

作者：

Tabarraei, Hadi ^{[1
,2
]}

Hassan, Jalal ^{[2
]}

Parvizi, Mohammad Reza ^{[1
]}

Golshahi, Hannaneh ^{[3
]}

Keshavarz-Tarikhi, Hossain ^{[4
]}

机构：

[1] AJA Univ Med Sci Tehran, Tehran, Iran

[2] Univ Tehran, Fac Vet Med, Dept Comparat Biosci, Div Toxicol, Tehran, Iran

[3] ACECR, Avicenna Res Inst, Reprod Biotechnol Res Ctr, Tehran, Iran

[4] Univ Tehran, Fac Vet Med, Dept Comparat Biosci, Div Pharmacol, Tehran, Iran

来源：

TOXICOLOGY REPORTS | 2019年 / 6卷

关键词：

Black caraway (Bunium persicum); Essential oil; Acute toxicity; Sub-acute toxicity; Rat; CARUM-CARVI L; ANTIBACTERIAL ACTIVITY; MAJOR COMPONENTS; EXTRACT;

D O I：

10.1016/j.toxrep.2019.08.010

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The aim of the present study was to evaluate the acute toxicity as lethal dose 50% (LD50) and sub-acute toxicity of the black caraway Bunium persicum (Bioss) seed essential oil in male Wistar rats. The compounds of B. persicum were identified by GC/MS and amount of each compound was evaluated. 21 different compounds were determined in the essential oil and the main components were: carvone, p-cymene, gamma-terpinene, p-cymene-8-ol, limonene, isoterpinolene, and 2-beta pinene. For acute toxicity evaluation, the animals were randomly divided into nine group (n = 6) and received 500, 1000, 1500, 2000, 2500, 3000, 3500 and 4000 mg/kg seed essential oil, respectively and the LD50 value for black caraway seed essential oil was obtained above 4000 mg/kg body weight. According to data, treatment with the black caraway seed essential oil sub-acute toxicity study attenuated histopathological changes in lung, liver, kidney, testes and spleen tissues and the results of this study show that the black caraway essential oil can not affect the immune and blood system, important enzymes and vital organs of the body..

引用

页码：869 / 874

页数：6

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