A Case of Metastatic Fumarate Hydratase-Deficient-like Renal Cell Carcinoma Successfully Managed by Ipilimumab plus Nivolumab

被引：0

作者：

Sekito, Takanori ^{[1
]}

Takamoto, Atsushi ^{[1
]}

Kobayashi, Yasuyuki ^{[1
]}

Mitsui, Masao ^{[4
]}

Watari, Shogo ^{[1
]}

Kubota, Risa ^{[1
]}

Sadahira, Takuya ^{[1
]}

Iwata, Takehiro ^{[1
]}

Nishimura, Shingo ^{[1
]}

Edamura, Kohei ^{[1
]}

Sako, Tomoko ^{[1
]}

Araki, Motoo ^{[1
]}

Watanabe, Masami ^{[1
]}

Watanabe, Toyohiko ^{[1
]}

Shibata, Rei ^{[2
]}

Ennishi, Daisuke ^{[3
]}

Nasu, Yasutomo ^{[1
]}

机构：

[1] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Urol, Okayama 7008558, Japan

[2] Okayama Univ Hosp, Dept Pathol, Okayama 7008558, Japan

[3] Okayama Univ Hosp, Dept Hematol & Oncol, Okayama 7008558, Japan

[4] Kurashiki Med Ctr, Dept Urol, Kurashiki, Okayama 7018522, Japan

来源：

ACTA MEDICA OKAYAMA | 2021年 / 75卷 / 03期

关键词：

fumarate hydratase; fumarate hydratase-deficient renal cell carcinoma; renal cell carcinoma; ipilimumab; nivolumab; HEREDITARY LEIOMYOMATOSIS; MUTATION; TUMORS;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We report a 62-year-old male with metastatic fumarate hydratase-deficient renal cell carcinoma (FH-deficient RCC) without fumarate hydratase (FH) mutation (FH-deficient-like RCC). The International Metastatic RCC Database Consortium risk score was intermediate, and immunotherapy with nivolumab and ipilimumab (Ipi/Nivo) was initiated. Four cydes of Ipi/Nivo and 5 cydes of nivolumab resulted in a complete response of the metastases. Hypophysitis occurred as an immune-related adverse event after four cydes of Ipi/Nivo. The prognosis of patients with FH-deficient RCC is generally poor. Few reports of FH-deficient RCC successfully treated with Ipi/Nivo have been published. Ipi/Nivo can be effective for treating FH-deficient RCC.

引用

页码：397 / 402

页数：6

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