Schizophrenic patients treated with clozapine or olanzapine perform better on theory of mind tasks than those treated with risperidone or typical antipsychotic medications

被引:38
作者
Savina, Ioulia
Beninger, Richard J.
机构
[1] Queens Univ, Dept Psychol, Kingston, ON K7L 3N6, Canada
[2] Queens Univ, Dept Psychiat, Kingston, ON K7L 3N6, Canada
关键词
schizophrenia; antipsychotics; atypical; typical; social cognition; theory of mind;
D O I
10.1016/j.schres.2007.04.010
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Theory of mind (ToM), the ability to attribute mental states to others, is associated with medial prefrontal cortical (mPFC) activity and is impaired in schizophrenia. Olanzapine or clozapine but not typical antipsychotics or risperidone preferentially affect c-fos expression in mPFC in animals. We tested the hypothesis that schizophrenic patients treated with different antipsychotics would perform differently on ToM tasks. Groups receiving Typicals (n = 23), Clozapine (n = 18), Olanzapine (n = 20) or Risperidone (n = 23) and a Control group of healthy volunteers (n = 24) were matched for age, gender, handedness and education. ToM functioning was assessed with picture sequence, second-order belief and faux-pas tests. Schizophrenic groups performed similarly to controls on non-ToM conditions. The Olanzapine and Clozapine groups performed similarly to Controls on ToM tasks. The Typicals and Risperidone groups performed worse than the other groups on ToM tasks. We concluded that ToM performance of schizophrenic patients is influenced by the antipsychotic they are taking. Our results suggest that olanzapine or clozapine but not typicals or risperidone may improve or protect ToM ability. (C) 2007 Elsevier B.V. All rights reserved.
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页码:128 / 138
页数:11
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