Coronary functional assessment in non-obstructive coronary artery disease: Present situation and future direction

被引：12

作者：

Zhai, Changlin ^{[1
]}

Fan, Hongyan ^{[1
]}

Zhu, Yujuan ^{[1
]}

Chen, Yunqing ^{[2
]}

Shen, Liang ^{[1
]}

机构：

[1] Jiaxing Univ, Affiliated Hosp, Dept Cardiol, Jiaxing, Peoples R China

[2] Jiaxing Univ, Affiliated Hosp, Dept Infect Dis, Jiaxing, Peoples R China

来源：

FRONTIERS IN CARDIOVASCULAR MEDICINE | 2022年 / 9卷

关键词：

coronary functional assessment; INOCA; MINOCA; microvascular dysfunction; vasomotion abnormality; FRACTIONAL FLOW RESERVE; COMPUTED-TOMOGRAPHY ANGIOGRAPHY; MYOCARDIAL-INFARCTION; DIAGNOSTIC-ACCURACY; MICROVASCULAR DYSFUNCTION; MICROCIRCULATORY RESISTANCE; INTRAVASCULAR ULTRASOUND; VELOCITY RESERVE; WORKING GROUP; CHEST-PAIN;

D O I：

10.3389/fcvm.2022.934279

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Non-obstructive coronary artery disease (CAD), which is defined as coronary stenosis <50%, has been increasingly recognized as an emerging entity in clinical practice. Vasomotion abnormality and coronary microvascular dysfunction are two major mechanisms contributing to the occur of angina with non-obstructive CAD. Although routine coronary functional assessment is limited due to several disadvantages, functional evaluation can help to understand the pathophysiological mechanism and/or to exclude specific etiologies. In this review, we summarized the potential mechanisms involved in ischemia with non-obstructive coronary arteries (INOCA) and myocardial infarction with non-obstructive coronary arteries (MINOCA), the two major form of non-obstructive CAD. Additionally, we reviewed currently available functional assessment indices and their use in non-obstructive CAD. Furthermore, we speculated that novel technique combined anatomic and physiologic parameters might provide more individualized therapeutic choice for patients with non-obstructive CAD.

引用

页数：11

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