Maternal Dyslipidemia, Plasma Branched-Chain Amino Acids, and the Risk of Child Autism Spectrum Disorder: Evidence of Sex Difference

被引：11

作者：

Panjwani, Anita A. ^{[1
]}

Ji, Yuelong ^{[2
]}

Fahey, Jed W. ^{[1
,3
,4
]}

Palmer, Amanda ^{[1
]}

Wang, Guoying ^{[2
]}

Hong, Xiumei ^{[2
]}

Zuckerman, Barry ^{[5
,6
]}

Wang, Xiaobin ^{[2
,7
]}

机构：

[1] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Ctr Human Nutr, Dept Int Hlth, Baltimore, MD USA

[2] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Ctr Early Life Origins Dis, Dept Populat Family & Reprod Hlth, 615 N Wolfe St,E4132, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Cullman Chemoprotect Ctr, Dept Pharmacol & Mol Sci, Baltimore, MD USA

[4] Johns Hopkins Univ, Sch Med, Dept Med, Div Clin Pharmacol, Baltimore, MD USA

[5] Boston Univ, Sch Med, Dept Pediat, Boston, MA 02118 USA

[6] Boston Univ, Boston Med Ctr, Boston, MA 02118 USA

[7] Johns Hopkins Univ, Sch Med, Dept Pediat, Div Gen Pediat & Adolescent Med, Baltimore, MD 21205 USA

来源：

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2020年 / 50卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Autism spectrum disorder; Maternal cholesterols; Pre; and perinatal risk factors; Sex differences; Branched-chain amino acids; Metabolomics; LOW-DENSITY-LIPOPROTEIN; CHOLESTEROL-METABOLISM; PREGNANCY; HYPERCHOLESTEROLEMIA; ABNORMALITIES; ASSOCIATION; POPULATION; PREVALENCE; PROFILES; STRENGTH;

D O I：

10.1007/s10803-019-04264-x

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

In contrast to the well-observed associations between obesity, diabetes, and autism spectrum disorder (ASD), the roles of maternal dyslipidemia and sex disparity in ASD have not been well-studied. We examined the joint associations of maternal plasma cholesterols, branched-chain amino acids (BCAAs) and child sex on child ASD risk. We analyzed data from 756 mother-infant pairs (86 ASD) from the Boston Birth Cohort. Maternal plasma cholesterols and BCAAs were measured in samples collected 24-72 h postpartum. We found that in this urban, low-income prospective birth cohort, low maternal high-density lipoprotein cholesterol (HDL-C), above-median maternal plasma BCAA concentrations, and male sex additively or synergistically increased risk of ASD. Additional studies are necessary to confirm our findings.

引用

页码：540 / 550

页数：11

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