共 111 条
Magnetic resonance imaging relaxation time in Alzheimer's disease
被引:34
作者:

Tang, Xiang
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机构:
Soochow Univ, Dept Neurol, Affiliated Hosp 1, 899 Pinghai Rd, Suzhou 215006, Jiangsu, Peoples R China Soochow Univ, Dept Neurol, Affiliated Hosp 1, 899 Pinghai Rd, Suzhou 215006, Jiangsu, Peoples R China

Cai, Feng
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Soochow Univ, Dept Orthoped, Affiliated Hosp 1, 899 Pinghai Rd, Suzhou 215006, Jiangsu, Peoples R China Soochow Univ, Dept Neurol, Affiliated Hosp 1, 899 Pinghai Rd, Suzhou 215006, Jiangsu, Peoples R China

Ding, Dong-Xue
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机构:
Soochow Univ, Dept Neurol, Affiliated Hosp 1, 899 Pinghai Rd, Suzhou 215006, Jiangsu, Peoples R China Soochow Univ, Dept Neurol, Affiliated Hosp 1, 899 Pinghai Rd, Suzhou 215006, Jiangsu, Peoples R China

Zhang, Lu-Lu
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h-index: 0
机构:
Soochow Univ, Dept Neurol, Affiliated Hosp 1, 899 Pinghai Rd, Suzhou 215006, Jiangsu, Peoples R China Soochow Univ, Dept Neurol, Affiliated Hosp 1, 899 Pinghai Rd, Suzhou 215006, Jiangsu, Peoples R China

Cai, Xiu-Ying
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h-index: 0
机构:
Soochow Univ, Dept Neurol, Affiliated Hosp 1, 899 Pinghai Rd, Suzhou 215006, Jiangsu, Peoples R China Soochow Univ, Dept Neurol, Affiliated Hosp 1, 899 Pinghai Rd, Suzhou 215006, Jiangsu, Peoples R China

Fang, Qi
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h-index: 0
机构:
Soochow Univ, Dept Neurol, Affiliated Hosp 1, 899 Pinghai Rd, Suzhou 215006, Jiangsu, Peoples R China Soochow Univ, Dept Neurol, Affiliated Hosp 1, 899 Pinghai Rd, Suzhou 215006, Jiangsu, Peoples R China
机构:
[1] Soochow Univ, Dept Neurol, Affiliated Hosp 1, 899 Pinghai Rd, Suzhou 215006, Jiangsu, Peoples R China
[2] Soochow Univ, Dept Orthoped, Affiliated Hosp 1, 899 Pinghai Rd, Suzhou 215006, Jiangsu, Peoples R China
基金:
中国国家自然科学基金;
关键词:
Magnetic resonance imaging;
T1 relaxation time;
T2 relaxation time;
Alzheimer's disease;
Biomarker;
TRANSGENIC MOUSE MODELS;
WHITE-MATTER;
MULTIPLE-SCLEROSIS;
IN-VIVO;
T-2;
RELAXATION;
QUANTITATIVE MRI;
MULTIINFARCT DEMENTIA;
COGNITIVE IMPAIRMENT;
OXIDATIVE STRESS;
BRAIN-TISSUE;
D O I:
10.1016/j.brainresbull.2018.05.004
中图分类号:
Q189 [神经科学];
学科分类号:
071006 ;
摘要:
The magnetic resonance imaging (MRI) relaxation time constants, T1 and T2, are sensitive to changes in brain tissue microstructure integrity. Quantitative T1 and T2 relaxation times have been proposed to serve as non-invasive biomarkers of Alzheimer's disease (AD), in which alterations are believed to not only reflect AD-related neuropathology but also cognitive impairment. In this review, we summarize the applications and key findings of MRI techniques in the context of both AD subjects and AD transgenic mouse models. Furthermore, the possible mechanisms of relaxation time alterations in AD will be discussed. Future studies could focus on relaxation time alterations in the early stage of AD, and longitudinal studies are needed to further explore relaxation time alterations during disease progression.
引用
收藏
页码:176 / 189
页数:14
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