Magnetic resonance imaging relaxation time in Alzheimer's disease

被引：29

作者：

Tang, Xiang ^{[1
]}

Cai, Feng ^{[2
]}

Ding, Dong-Xue ^{[1
]}

Zhang, Lu-Lu ^{[1
]}

Cai, Xiu-Ying ^{[1
]}

Fang, Qi ^{[1
]}

机构：

[1] Soochow Univ, Dept Neurol, Affiliated Hosp 1, 899 Pinghai Rd, Suzhou 215006, Jiangsu, Peoples R China

[2] Soochow Univ, Dept Orthoped, Affiliated Hosp 1, 899 Pinghai Rd, Suzhou 215006, Jiangsu, Peoples R China

来源：

BRAIN RESEARCH BULLETIN | 2018年 / 140卷

基金：

中国国家自然科学基金;

关键词：

Magnetic resonance imaging; T1 relaxation time; T2 relaxation time; Alzheimer's disease; Biomarker; TRANSGENIC MOUSE MODELS; WHITE-MATTER; MULTIPLE-SCLEROSIS; IN-VIVO; T-2; RELAXATION; QUANTITATIVE MRI; MULTIINFARCT DEMENTIA; COGNITIVE IMPAIRMENT; OXIDATIVE STRESS; BRAIN-TISSUE;

D O I：

10.1016/j.brainresbull.2018.05.004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The magnetic resonance imaging (MRI) relaxation time constants, T1 and T2, are sensitive to changes in brain tissue microstructure integrity. Quantitative T1 and T2 relaxation times have been proposed to serve as non-invasive biomarkers of Alzheimer's disease (AD), in which alterations are believed to not only reflect AD-related neuropathology but also cognitive impairment. In this review, we summarize the applications and key findings of MRI techniques in the context of both AD subjects and AD transgenic mouse models. Furthermore, the possible mechanisms of relaxation time alterations in AD will be discussed. Future studies could focus on relaxation time alterations in the early stage of AD, and longitudinal studies are needed to further explore relaxation time alterations during disease progression.

引用

页码：176 / 189

页数：14

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