Synthesis and Antiproliferative Activities of Novel O-Benzyl Salicylamide Derivatives

被引：3

作者：

Dusek, Jan ^{[1
]}

Imramovsky, Ales ^{[1
]}

Pauk, Karel ^{[1
]}

Jorda, Radek ^{[2
,3
]}

Reznickova, Eva ^{[2
,3
]}

Krystof, Vladimir ^{[2
,3
]}

机构：

[1] Univ Pardubice, Fac Chem Technol, Inst Organ Chem & Technol, Studentska 573, Pardubice 53210, Czech Republic

[2] Palacky Univ, Ctr Reg Hana Biotechnol & Agr Res, Lab Growth Regulators, Slechtitelu 27, Olomouc 78371, Czech Republic

[3] Inst Expt Bot ASCR, Slechtitelu 27, Olomouc 78371, Czech Republic

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2017年 / 14卷 / 06期

关键词：

Salicylamides; antiproliferative activity; cytotoxic activity; pharmacological activity; amines; GROWTH-FACTOR RECEPTOR; BIOLOGICAL EVALUATION; INHIBITORS; SALICYLANILIDES; ANALOGS;

D O I：

10.2174/1570180813666161020113827

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Background: On the basis that various substituted salicylamides have shown interesting biological properties, we designed and synthesized new salicylamide derivatives with dipeptide moieties. Methods: The synthesis was based on the gradual building of target molecules and provided optically pure compounds. Conclusion: The obtained compounds were tested for their antiproliferative effect against three leukaemia cell lines in vitro and displayed GI(50) values in the mid-micromolar range.

引用

页码：662 / 671

页数：10

共 50 条

[21] Syntheses and antiproliferative activities of novel diarylthiosemicarbazide derivatives
Xin Zhai
Ying He
Zhen Yang
Ping Gong
Chemical Research in Chinese Universities, 2013, 29 : 62 - 66
[22] EFFECT OF AMINES ON O-BENZYL GROUP HYDROGENOLYSIS
CZECH, BP
BARTSCH, RA
JOURNAL OF ORGANIC CHEMISTRY, 1984, 49 (21): : 4076 - 4078
[23] Syntheses and Antiproliferative Activities of Novel Diarylthiosemicarbazide Derivatives
Zhai Xin
He Ying
Yang Zhen
Gong Ping
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2013, 29 (01) : 62 - 66
[24] An alternative approach to (S)- and (R)-2-methylglycidol O-benzyl ether derivatives
Avenoza, A
Cativiela, C
Peregrina, JM
Sucunza, D
Zurbano, MM
TETRAHEDRON-ASYMMETRY, 2001, 12 (09) : 1383 - 1388
[25] Design, synthesis, and antiproliferative activities of novel thiazolyl-pyrazole hybrid derivatives
Kuzu, Burak
Erguc, Ali
Karakus, Fuat
Arzuk, Ege
MEDICINAL CHEMISTRY RESEARCH, 2023, 32 (08) : 1690 - 1700
[26] SYNTHESIS AND ANTIPROLIFERATIVE ACTIVITIES OF DIARYL THIOETHER DERIVATIVES
POIRIER, D
AUGER, S
MERAND, Y
LABRIE, F
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1992, 204 : 111 - MEDI
[27] Synthesis and antiproliferative activities of aminoalkylated polymethoxyflavonoid derivatives
Li, Xue-Li
Zhang, Yan-Hua
Wang, Cai-Fang
Wang, Qiu-An
NATURAL PRODUCT RESEARCH, 2019, 33 (06) : 827 - 834
[28] Design, synthesis, and antiproliferative activities of novel thiazolyl-pyrazole hybrid derivatives
Burak Kuzu
Ali Ergüç
Fuat Karakuş
Ege Arzuk
Medicinal Chemistry Research, 2023, 32 : 1690 - 1700
[29] Synthesis and Antiproliferative Activities of Novel Substituted 5-Anilino-α-Glucofuranose Derivatives
Zhang, Yaling
Wang, Lili
Sun, Baoli
Li, Xiabing
Hou, Qiaoli
Wang, Wei
Li, Baolin
CHEMISTRY & BIODIVERSITY, 2020, 17 (04)
[30] Synthesis of Novel Ring B Abeo-sterol Derivatives and their Antiproliferative Activities
Gan, Chunfang
Fan, Lianghua
Huang, Yanmin
Liu, Zhiping
Cui, Jianguo
MEDICINAL CHEMISTRY, 2013, 9 (06) : 846 - 854

← 1 2 3 4 5 →