Synthesis and Antiproliferative Activities of Novel O-Benzyl Salicylamide Derivatives

被引：3

作者：

Dusek, Jan ^{[1
]}

Imramovsky, Ales ^{[1
]}

Pauk, Karel ^{[1
]}

Jorda, Radek ^{[2
,3
]}

Reznickova, Eva ^{[2
,3
]}

Krystof, Vladimir ^{[2
,3
]}

机构：

[1] Univ Pardubice, Fac Chem Technol, Inst Organ Chem & Technol, Studentska 573, Pardubice 53210, Czech Republic

[2] Palacky Univ, Ctr Reg Hana Biotechnol & Agr Res, Lab Growth Regulators, Slechtitelu 27, Olomouc 78371, Czech Republic

[3] Inst Expt Bot ASCR, Slechtitelu 27, Olomouc 78371, Czech Republic

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2017年 / 14卷 / 06期

关键词：

Salicylamides; antiproliferative activity; cytotoxic activity; pharmacological activity; amines; GROWTH-FACTOR RECEPTOR; BIOLOGICAL EVALUATION; INHIBITORS; SALICYLANILIDES; ANALOGS;

D O I：

10.2174/1570180813666161020113827

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Background: On the basis that various substituted salicylamides have shown interesting biological properties, we designed and synthesized new salicylamide derivatives with dipeptide moieties. Methods: The synthesis was based on the gradual building of target molecules and provided optically pure compounds. Conclusion: The obtained compounds were tested for their antiproliferative effect against three leukaemia cell lines in vitro and displayed GI(50) values in the mid-micromolar range.

引用

页码：662 / 671

页数：10

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