Factors Diminishing Cytoadhesion of Red Blood Cells Infected by Plasmodium falciparum in Arterioles

被引:6
作者
Ishida, Shunichi [1 ]
Ami, Akihisa [1 ]
Imai, Yohsuke [2 ]
机构
[1] Tohoku Univ, Grad Sch Biomed Engn, Sendai, Miyagi, Japan
[2] Tohoku Univ, Sch Engn, Sendai, Miyagi, Japan
关键词
INTERCELLULAR-ADHESION MOLECULE-1; MICROVASCULAR ENDOTHELIAL-CELLS; SHEAR-STRESS QUANTIFICATION; MEMBRANE GLYCOPROTEIN; CHONDROITIN SULFATE; FLOW CONDITIONS; IN-VIVO; MALARIA; ERYTHROCYTES; RECEPTOR;
D O I
10.1016/j.bpj.2017.07.020
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Cytoadhesion of red blood cells infected by Plasmodium falciparum (Pf-IRBCs) is predominantly found in postcapillary venules, rather than in arterioles. However, factors influencing this phenomenon remain unclear. Here, we conduct a systematic study using a numerical model coupling the fluid and solid mechanics of the cells and cellular environment with the biochemical ligand-receptor interaction. Our results show that, once a Pf-IRBC adheres to the vascular wall, the Pf-IRBC can withstand even arteriole shear stresses, and exhibits either rolling or firm adhesion. We also perform a simulation of the multistep process of cytoadhesion, consisting of flow, margination, capture, and rolling or firm adhesion. This multistep simulation suggests that a lower probability of contact with the vascular wall at high shear rates may diminish adherent Pf-IRBCs in the arterioles.
引用
收藏
页码:1163 / 1172
页数:10
相关论文
共 54 条
  • [21] Margination of red blood cells infected by Plasmodium falciparum in a microvessel
    Imai, Yohsuke
    Nakaaki, Keita
    Kondo, Hitoshi
    Ishikawa, Takuji
    Lim, Chwee Teck
    Yamaguchi, Takami
    [J]. JOURNAL OF BIOMECHANICS, 2011, 44 (08) : 1553 - 1558
  • [22] Modeling of hemodynamics arising from malaria infection
    Imai, Yohsuke
    Kondo, Hitoshi
    Ishikawa, Takuji
    Lim, Chwee Teck
    Yamaguchi, Takami
    [J]. JOURNAL OF BIOMECHANICS, 2010, 43 (07) : 1386 - 1393
  • [23] A numerical model of a red blood cell infected by Plasmodium falciparum malaria: coupling cell mechanics with ligand-receptor interactions
    Ishida, Shunichi
    Imai, Yohsuke
    Ichikawa, Yuki
    Nix, Stephanie
    Matsunaga, Daiki
    Omori, Toshihiro
    Ishikawa, Takuji
    [J]. SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS, 2016, 17 (01) : 454 - 461
  • [24] KAUL DK, 1991, BLOOD, V78, P812
  • [25] Hemodynamic Analysis of Microcirculation in Malaria Infection
    Kondo, Hitoshi
    Imai, Yohsuke
    Ishikawa, Takuji
    Tsubota, Ken-ichi
    Yamaguchi, Takami
    [J]. ANNALS OF BIOMEDICAL ENGINEERING, 2009, 37 (04) : 702 - 709
  • [26] Koutsiaris AG, 2007, BIORHEOLOGY, V44, P375
  • [27] Wall shear stress quantification in the human conjunctival pre-capillary arterioles in vivo
    Koutsiaris, Aristotle G.
    Tachmitzi, Sophia V.
    Batis, Nick
    [J]. MICROVASCULAR RESEARCH, 2013, 85 : 34 - 39
  • [28] Observations on the internal and surface morphology of malaria infected blood cells using optical and atomic force microscope
    Li, Ang
    Mansoor, Ammar H.
    Tan, Kevin S. W.
    Lim, C. T.
    [J]. JOURNAL OF MICROBIOLOGICAL METHODS, 2006, 66 (03) : 434 - 439
  • [29] Molecular Mechanistic Insights into the Endothelial Receptor Mediated Cytoadherence of Plasmodium falciparum-Infected Erythrocytes
    Li, Ang
    Lim, Tong Seng
    Shi, Hui
    Yin, Jing
    Tan, Swee Jin
    Li, Zhengjun
    Low, Boon Chuan
    Tan, Kevin Shyong Wei
    Lim, Chwee Teck
    [J]. PLOS ONE, 2011, 6 (03):
  • [30] Spectrin-level modeling of the cytoskeleton and optical tweezers stretching of the erythrocyte
    Li, J
    Dao, M
    Lim, CT
    Suresh, S
    [J]. BIOPHYSICAL JOURNAL, 2005, 88 (05) : 3707 - 3719