Blood-Brain Barrier Permeable Gold Nanoparticles: An Efficient Delivery Platform for Enhanced Malignant Glioma Therapy and Imaging

被引：189

作者：

Cheng, Yu ^{[1
]}

Dai, Qing ^{[2
,3
]}

Morshed, Ramin A. ^{[1
]}

Fan, Xiaobing ^{[4
]}

Wegscheid, Michelle L. ^{[1
]}

Wainwright, Derek A. ^{[1
]}

Han, Yu ^{[1
]}

Zhang, Lingjiao ^{[1
]}

Auffinger, Brenda ^{[1
]}

Tobias, Alex L. ^{[1
]}

Rincon, Esther ^{[1
]}

Thaci, Bart ^{[1
]}

Ahmed, Atique U. ^{[1
]}

Warnke, Peter C. ^{[1
]}

He, Chuan ^{[2
,3
]}

Lesniak, Maciej S. ^{[1
]}

机构：

[1] Univ Chicago, Brain Tumor Ctr, Chicago, IL 60637 USA

[2] Univ Chicago, Inst Biophys Dynam, Dept Chem, Chicago, IL 60637 USA

[3] Univ Chicago, Howard Hughes Med Inst, Chicago, IL 60637 USA

[4] Univ Chicago, Dept Radiol, Chicago, IL 60637 USA

来源：

SMALL | 2014年 / 10卷 / 24期

关键词：

ADJUVANT TEMOZOLOMIDE; LOCAL-DELIVERY; DRUG-DELIVERY; PARTICLE-SIZE; QUANTUM DOTS; TAT; TUMORS; DOXORUBICIN; CELLS; GLIOBLASTOMA;

D O I：

10.1002/smll.201400654

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The blood-brain barrier (BBB) remains a formidable obstacle in medicine, preventing efficient penetration of chemotherapeutic and diagnostic agents to malignant gliomas. Here, a transactivator of transcription (TAT) peptide-modified gold nanoparticle platform (TAT-Au NP) with a 5 nm core size is demonstrated to be capable of crossing the BBB efficiently and delivering cargoes such as the anticancer drug doxorubicin (Dox) and Gd3+ contrast agents to brain tumor tissues. Treatment of mice bearing intracranial glioma xenografts with pH-sensitive Dox-conjugated TAT-Au NPs via a single intravenous administration leads to significant survival benefit when compared to the free Dox. Furthermore, it is demonstrated that TAT-Au NPs are capable of delivering Gd3+ chelates for enhanced brain tumor imaging with a prolonged retention time of Gd3+ when compared to the free Gd3+ chelates. Collectively, these results show promising applications of the TAT-Au NPs for enhanced malignant brain tumor therapy and non-invasive imaging.

引用

页码：5137 / 5150

页数：14

共 48 条

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