Biomolecular condensates in autophagy regulation

被引：30

作者：

Fujioka, Yuko ^{[1
]}

Noda, Nobuo N. ^{[1
]}

机构：

[1] Inst Microbial Chem, Shinagawa Ku, 3-14-23 Kamiosaki, Tokyo 1410021, Japan

来源：

CURRENT OPINION IN CELL BIOLOGY | 2021年 / 69卷

关键词：

Autophagy; PAS; Ape1; p62; Phase separation; Biomolecular condensate; Selective autophagy; Bulk autophagy; Cvt pathway; SELECTIVE AUTOPHAGY; AMINOPEPTIDASE-I; STRUCTURAL BASIS; ATG1; KINASE; EARLY STEPS; PROTEIN; CYTOPLASM; RECEPTOR; P62; TOR;

D O I：

10.1016/j.ceb.2020.12.011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Autophagy is an intracellular degradation system that contributes to cellular homeostasis. Autophagosome formation is a landmark event in autophagy, which sequesters and delivers cytoplasmic components to the lysosome for degradation. Based on selectivity, autophagy can be classified into bulk and selective autophagy, which are mechanistically distinct from each other, especially in the requirement of cargos for autophagosome formation. Recent studies revealed that liquid-like biomolecular condensates, which are formed through liquid-liquid phase separation, regulate the autophagosome formation of both bulk and selective autophagy. Here, we focus on recent findings on the involvement of biomolecular condensates in autophagy regulation and discuss their significance.

引用

页码：23 / 29

页数：7

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