Chronic Hind Limb Ischemia Reduces Myocardial Ischemia-Reperfusion Injury in the Rabbit Heart by Promoting Coronary Angiogenesis/Arteriogenesis

被引：0

作者：

Varnavas, Varnavas C. ^{[2
]}

Paraskevas, Kosmas I. ^{[1
]}

Iliodromitis, Efstathios K. ^{[3
]}

Zoga, Anastasia ^{[3
]}

Glava, Irini ^{[2
]}

Kaklamanis, Loukas ^{[4
]}

Spartinos, John ^{[2
]}

Lyras, Theodore ^{[2
]}

Kremastinos, Dimitrios T. ^{[3
]}

Mikhailidis, Dimitri P. ^{[5
]}

Kyriakides, Zenon S. ^{[2
]}

机构：

[1] Red Cross Hosp, Dept Vasc Surg, Athens 11526, Greece

[2] Red Cross Hosp, Dept Cardiol 2, Athens 11526, Greece

[3] Univ Athens, Sch Med, Attikon Gen Hosp, Dept Cardiol 2, GR-11527 Athens, Greece

[4] Onassis Cardiac Ctr, Athens, Greece

[5] UCL, Dept Clin Biochem, Vasc Dis Prevent Clin, London, England

来源：

IN VIVO | 2010年 / 24卷 / 02期

关键词：

Chronic hind limb ischemia; angiogenesis; ischemia reperfusion injury; remote ischemic preconditioning; infarct size; arteriogenesis; CHANNEL-DEPENDENT MECHANISM; INFARCT SIZE; NITRIC-OXIDE; CHEST-PAIN; ARTERIOGENESIS; ANGIOGENESIS; GROWTH; STIMULATION; PROTECTION; MODEL;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Background/Aim: Application of ischemic injury in a remote organ may provide protection of other tissues against ischemia. We hypothesized that ischemia in the rabbit hind limb protects against myocardial ischemia by increasing angiogenesis/arteriogenesis. Materials and Methods: In the first experiment, severe limb ischemia (LI) was induced in 26 New Zealand White rabbits by excision of the femoral artery while another 26 served as controls (no ischemia; sham operation [SHO]). Four weeks later, the blood vessels of the subendocardial and intramyocardial areas of the excised hearts were counted. In the second experiment, 14 LI rabbits and 14 SHO controls were subjected to 30 min of regional heart ischemia and 3 h reperfusion. Infarct size and the areas at-risk were determined. Results: Compared with controls, LI rabbits showed more subendocardial (103 +/- 14 vs. 113 +/- 13 capillaries/mm(2), respectively; p=0.01) and intramyocardial blood vessels (102 +/- 12 vs. 114 +/- 16 capillaries/mm2, respectively; p=0.009). LI rabbits had significantly smaller infarct size compared with the SHO animals (infarct areas/areas-at-risk: 14.37 +/- 11.23% vs. 31.31 +/- 13.73%, respectively; p=0.003). Conclusion: Chronic hind LI reduces myocardial infarct size by promoting coronary angiogenesis/arteriogenesis in an experimental model.

引用

页码：147 / 152

页数：6

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