Transmission of Methicillin-Resistant Staphylococcus aureus via Deceased Donor Liver Transplantation Confirmed by Whole Genome Sequencing

被引：39

作者：

Altman, D. R. ^{[1
]}

Sebra, R. ^{[2
]}

Hand, J. ^{[1
]}

Attie, O. ^{[2
]}

Deikus, G. ^{[2
]}

Carpini, K. W. D. ^{[3
]}

Patel, G. ^{[1
]}

Rana, M. ^{[1
]}

Arvelakis, A. ^{[4
]}

Grewal, P. ^{[4
]}

Dutta, J. ^{[2
]}

Rose, H. ^{[5
]}

Shopsin, B. ^{[5
]}

Daefler, S. ^{[1
]}

Schadt, E. ^{[2
]}

Kasarskis, A. ^{[2
]}

van Bakel, H. ^{[2
]}

Bashir, A. ^{[2
]}

Huprikar, S. ^{[1
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Med, Div Infect Dis, New York, NY 10029 USA

[2] Icahn Sch Med Mt Sinai, Inst & Dept Genet & Genom Sci, New York, NY 10029 USA

[3] New York Organ Donor Network, New York, NY USA

[4] Icahn Sch Med Mt Sinai, Recanati Miller Transplant Inst, New York, NY 10029 USA

[5] NYU, Sch Med, Dept Med, Div Infect Dis, New York, NY USA

来源：

AMERICAN JOURNAL OF TRANSPLANTATION | 2014年 / 14卷 / 11期

关键词：

BACTEREMIA; RECIPIENTS; VIRULENCE; ORGANS; TOOL;

D O I：

10.1111/ajt.12897

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Donor-derived bacterial infection is a recognized complication of solid organ transplantation (SOT). The present report describes the clinical details and successful outcome in a liver transplant recipient despite transmission of methicillin-resistant Staphylococcus aureus (MRSA) from a deceased donor with MRSA endocarditis and bacteremia. We further describe whole genome sequencing (WGS) and complete de novo assembly of the donor and recipient MRSA isolate genomes, which confirms that both isolates are genetically 100% identical. We propose that similar application of WGS techniques to future investigations of donor bacterial transmission would strengthen the definition of proven bacterial transmission in SOT, particularly in the presence of highly clonal bacteria such as MRSA. WGS will further improve our understanding of the epidemiology of bacterial transmission in SOT and the risk of adverse patient outcomes when it occurs. This report describes a successful outcome in a liver transplant recipient after deceased donor transmission of methicillin-resistant Staphylococcus aureus confirmed by whole genome sequencing. Also see case report by Wendt et al on page .

引用

页码：2640 / 2644

页数：5

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