The Relationship Between Ambient Atmospheric Fine Particulate Matter (PM2.5) and Glaucoma in a Large Community Cohort

被引：72

作者：

Chua, Sharon Y. L. ^{[1
,2
,3
,14
]}

Khawaja, Anthony P. ^{[1
,2
,3
,14
]}

Morgan, James ^{[4
,18
]}

Strouthidis, Nicholas ^{[1
,14
]}

Reisman, Charles ^{[5
]}

Dick, Andrew D. ^{[2
,3
,6
,7
]}

Khaw, Peng T. ^{[1
,2
,3
,14
]}

Patel, Praveen J. ^{[1
,14
]}

Foster, Paul J. ^{[1
,2
,3
]}

Atan, Denize ^{[7
]}

Aslam, Tariq ^{[8
]}

Barman, Sarah A. ^{[9
]}

Barrett, Jenny H. ^{[10
]}

Bishop, Paul ^{[8
]}

Bunce, Catey ^{[11
]}

Carare, Roxana O. ^{[12
]}

Chakravarthy, Usha ^{[13
]}

Chan, Michelle ^{[14
]}

Crabb, David P. ^{[15
]}

Day, Alexander ^{[14
]}

Desai, Parul ^{[14
]}

Dhillon, Bal ^{[16
]}

Egan, Cathy ^{[14
]}

Ennis, Sarah ^{[12
]}

Fruttiger, Marcus ^{[2
]}

Gallacher, John E. J. ^{[17
]}

Garway-Heath, David F. ^{[14
]}

Gibson, Jane ^{[12
]}

Gore, Dan ^{[14
]}

Guggenheim, Jeremy A. ^{[18
]}

Hammond, Chris J. ^{[11
]}

Hardcastle, Alison ^{[2
]}

Harding, Simon P. ^{[19
]}

Hogg, Ruth E. ^{[13
]}

Hysi, Pirro ^{[11
]}

Keane, Pearse A. ^{[14
]}

Lascaratos, Gerassimos ^{[20
]}

Lotery, Andrew J. ^{[12
]}

Macgillivray, Tom ^{[16
]}

Mackie, Sarah ^{[10
]}

McGaughey, Michelle ^{[13
]}

McGuinness, Bernadette ^{[13
]}

McKay, Gareth J. ^{[13
]}

McKibbin, Martin ^{[21
]}

Moore, Tony ^{[22
]}

Muthy, Zaynah A. ^{[14
]}

O'Sullivan, Eoin ^{[20
]}

Owen, Chris G. ^{[23
]}

Paterson, Euan ^{[13
]}

Peto, Tunde ^{[13
]}

机构：

[1] Natl Hlth Serv Fdn Trust, Moorfields Eye Hosp, Biomed Res Ctr, NIHR, London, England

[2] UCL Inst Ophthalmol, London, England

[3] UCL, UCL Inst Ophthalmol, London, England

[4] Cardiff Univ, Sch Optometry & Vis Sci, Cardiff, S Glam, Wales

[5] Topcon Healthcare Solut Res & Dev, Oakland, NJ USA

[6] Univ Bristol, Bristol Med Sch Translat Hlth Sci, Bristol, Avon, England

[7] Univ Bristol, Bristol, Avon, England

[8] Univ Manchester, Manchester, Lancs, England

[9] Kingston Univ, Kingston Upon Hull, Yorks, England

[10] Univ Leeds, Leeds, W Yorkshire, England

[11] Kings Coll London, London, England

[12] Univ Southampton, Southampton, Hants, England

[13] Queens Univ Belfast, Belfast, Antrim, North Ireland

[14] Moorfields, Biomed Res Ctr, London, England

[15] City Univ London, London, England

[16] Univ Edinburgh, Edinburgh, Midlothian, Scotland

[17] Univ Oxford, Oxford, England

[18] Cardiff Univ, Cardiff, S Glam, Wales

[19] Univ Liverpool, Liverpool, Merseyside, England

[20] Kings Coll Hosp NHS Fdn Trust, London, England

[21] Leeds Teaching Hosp NHS Trust, Leeds, W Yorkshire, England

[22] Univ Calif San Francisco, San Francisco, CA 94143 USA

[23] Univ London, London, England

[24] UCL, London, England

[25] Great Ormond St Hosp Sick Children, London, England

[26] UCL Inst Child Hlth, London, England

[27] St Georges Univ London, London, England

[28] Newcastle Univ, Newcastle Upon Tyne, Tyne & Wear, England

[29] Gloucestershire Hosp NHS Fdn Trust, Gloucester, England

[30] Biomed Res Ctr, London, England

[31] Univ Dundee, Dundee, Scotland

[32] Nottingham Univ Hosp NHS Trust, Nottingham, England

[33] Univ East Anglia, Norwich, Norfolk, England

来源：

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | 2019年 / 60卷 / 14期

关键词：

glaucoma; GCIPL; optical coherence tomography; intraocular pressure; fine particulate matter; OPEN-ANGLE GLAUCOMA; OPTICAL COHERENCE TOMOGRAPHY; LAND-USE REGRESSION; BLUE-MOUNTAINS-EYE; NERVE-FIBER LAYER; AIR-POLLUTION; INTRAOCULAR-PRESSURE; OXIDATIVE STRESS; BLOOD-FLOW; PREVALENCE;

D O I：

10.1167/iovs.19-28346

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

PURPOSE. Glaucoma is more common in urban populations than in others. Ninety percent of the world's population are exposed to air pollution above World Health Organization (WHO) recommended limits. Few studies have examined the association between air pollution and glaucoma. METHODS. Questionnaire data, ophthalmic measures, and ambient residential area air quality data for 111,370 UK Biobank participants were analyzed. Particulate matter with an aerodynamic diameter < 2.5 mu m (PM2.5) was selected as the air quality exposure of interest. Eye measures included self-reported glaucoma, intraocular pressure (IOP), and average thickness of macular ganglion cell-inner plexiform layer (GCIPL) across nine Early Treatment Diabetic Retinopathy Study (ETDRS) retinal subfields as obtained from spectral-domain optical coherence tomography. We examined the associations of PM2.5 concentration with self-reported glaucoma, IOP, and GCIPL. RESULTS. Participants resident in areas with higher PM 2 . 5 concentration were more likely to report a diagnosis of glaucoma (odds ratio = 1.06, 95% confidence interval [CI] = 1.01-1.12, per interquartile range [IQR] increase P = 0.02). Higher PM 2 . 5 concentration was also associated with thinner GCIPL (beta = -0.56 mu m, 95% CI = -0.63 to -0.49, per IQR increase, P = 1.2 x 10(-53)). A dose-response relationship was observed between higher levels of PM2.5 and thinner GCIPL (P < 0.001). There was no clinically relevant relationship between PM2.5 concentration and IOP. CONCLUSIONS. Greater exposure to PM(2.5 )is associated with both self-reported glaucoma and adverse structural characteristics of the disease. The absence of an association between PM2.5 and IOP suggests the relationship may occur through a non-pressure-dependent mechanism, possibly neurotoxic and/or vascular effects.

引用

页码：4915 / 4923

页数：9