Enzyme transformation to modulate the ligand-receptor interactions between small molecules

被引：12

作者：

Shi, Junfeng ^{[1
]}

Du, Xuewen ^{[1
]}

Yuan, Dan ^{[1
]}

Haburcak, Richard ^{[1
]}

Wu, Dongdong ^{[1
]}

Zhou, Ning ^{[1
]}

Xu, Bing ^{[1
]}

机构：

[1] Brandeis Univ, Dept Chem, Waltham, MA 02454 USA

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 23期

关键词：

D-ALA; VANCOMYCIN; BINDING; HYDROGELATION; NANOFIBRILS;

D O I：

10.1039/c4cc10374b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Enzymatic transformation is a fundamental process to control ligand-receptor interactions among proteins for signal transduction in cells. Here we report the first example of enzymatic transformation regulated ligand-receptor interactions of small molecules, in which enzymatic reaction changes the stoichiometry of the ligand-receptor binding from 1:1 to 1:2. We also show that this unique integration of enzymatic transformation and ligand-receptor interactions of small molecules is able to affect the fate of cells.

引用

收藏

页码：4899 / 4901

页数：3

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