Regulation of KIR expression in human T cells: a safety mechanism that may impair protective T-cell responses

被引：220

作者：

Mingari, MC ^{[1
]}

Moretta, A

Moretta, L

机构：

[1] Univ Genoa, Dipartimento Oncol Clin & Sperimentale, I-16132 Genoa, Italy

[2] Univ Genoa, Ist Istol & Embriol Gen, I-16132 Genoa, Italy

[3] Univ Genoa, Ist Patol Gen, I-16132 Genoa, Italy

[4] Ist Nazl Ric Canc, I-16132 Genoa, Italy

来源：

IMMUNOLOGY TODAY | 1998年 / 19卷 / 04期

关键词：

D O I：

10.1016/S0167-5699(97)01236-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Killer-cell inhibitory receptors (KIRs) are a new family of major histocompatibility complex (MHC) class I-specific receptors. KIRs allow natural killer cells to identify and lyse self cells that do not express sufficient amounts of MHC class I molecules. Here, Maria Cristina Mingari and colleagues view the expression of KIRs by cytolytic T lymphocytes and their regulation by certain cytokines as a double-edged sword.

引用

页码：153 / 157

页数：5

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