Reporting data from high-throughput screening of small-molecule libraries

被引：77

作者：

Inglese, James

Shamu, Caroline E.

Guy, R. Kiplin

机构：

[1] US Natl Inst Hlth, Chem Genom Ctr, Natl Human Genome Inst, Bethesda, MD 20892 USA

[2] Harvard Univ, Sch Med, ICCB, Longwood Screening Facil, Boston, MA 02115 USA

[3] St Jude Childrens Hosp, Dept Chem Biol & Therapeut, Memphis, TN 38105 USA

来源：

NATURE CHEMICAL BIOLOGY | 2007年 / 3卷 / 08期

关键词：

STATISTICAL PARAMETER; ASSAYS;

D O I：

10.1038/nchembio0807-438

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Publications reporting results of small-molecule screens are becoming more common as academic researchers increasingly make use of high-throughput screening (HTS) facilities. However, no standards have been formally established for reporting small-molecule screening data, and often key information important for the evaluation and interpretation of results is omitted in published HTS protocols. Here, we propose concise guidelines for reporting small-molecule HTS data.

引用

页码：438 / 441

页数：4

共 7 条

[1] Multiplex analysis of inflammatory signaling pathways using a high-content imaging system [J].