Potential rote of polyunsaturated fatty acids in diabetic retinopathy

被引:18
作者
Shen, Junhui [1 ]
Bi, Yan-Long [1 ]
Das, Undurti N. [2 ]
机构
[1] Tongji Univ, Sch Med, Tongji Hosp, Dept Ophthalmol, Shanghai 200065, Peoples R China
[2] UND Life Sci, Hefei, Peoples R China
关键词
vascular endothelial growth factor; hemorheology; inflammation; brain-derived neurotrophic factor; diabetic retinopathy; polyunsaturated fatty acids; ENDOTHELIAL GROWTH-FACTOR; METABOLIC SYNDROME-X; BLOOD-RETINAL BARRIER; ARACHIDONIC-ACID; HYPERTENSIVE PATIENTS; INDUCED CYTOTOXICITY; OXIDATIVE STRESS; OBESITY INDEXES; VEGF; MELLITUS;
D O I
10.5114/aoms.2014.47826
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Diabetic retinopathy (DR) is a serious complication of long-standing diabetes mellitus. It affects about 25% of all patients with diabetes mellitus and causes a significant decrease in the quality of life. Despite many years of research, the exact pathway that leads to the development and progression of DR is not clear. Recent studies suggest that polyunsaturated fatty acids (PUFAs) and their metabolites could play a significant role in DR. There is evidence to suggest that an imbalance between pro- and anti-inflammatory eicosanoids and enhanced production of pro-angiogenic factors may initiate the onset and progression of DR. This implies that PUFAs and their metabolites that possess anti-inflammatory actions and suppress the production of angiogenic factors could be employed in the prevention and management of DR.
引用
收藏
页码:1167 / 1174
页数:8
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