Objective: This study analyzed the effects of digital transformation on startup performance, mediated by the use of management information and moderated by entrepreneurial creativity. Method: A survey was conducted with technology startup managers listed in the StartupBase, and the structural equation modeling technique was applied to analyze the 215 questionnaires completed. Originality/Relevance: This study innovates by investigating the interrelationship of the constructs of digital transformation, management information use, entrepreneurial creativity, and organizational performance in startups. Results: The results denoted a positive influence of digital transformation on organizational performance. This suggests that if startups use new technologies, the chances of achieving the expected performance and surpassing their competitors are more significant. A mediation of the use of management information in this relationship was observed, indicating that using such information impacts the decision -making by managers. No moderation of entrepreneurial creativity was found in the proposed relationship, although creative entrepreneurs presumably can develop innovations through new technologies. Theoretical/Methodological contributions: The results contribute by bridging gaps identified in the literature insofar as they reveal that digital transformation and the use of management information are important drivers of organizational performance. Social/Management contributions: This study has practical implications by demonstrating that the digital transformation and the use of management information reflect on organizational performance, an important signal to managers about the primary focus to improve startup performance.