High-throughput target discovery using cell-based genetics

被引:11
作者
Jackson, RD [1 ]
Harrington, JI [1 ]
机构
[1] Athersys Inc, Cleveland, OH 44115 USA
关键词
D O I
10.1016/S1359-6446(04)03303-3
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
High-throughput target discovery requires robust disease models and the ability to rapidly survey the genome for function. In the post-genomics era, there has been a strong emphasis placed upon 'gene-to-function' approaches that take advantage of the large amount of gene sequence information now available. Here, we advocate a return to 'function-to-gene' approaches as a first step in target discovery (and validation), followed by hypothesis-driven research to validate new targets identified by their activity in cell-based disease models.
引用
收藏
页码:53 / 60
页数:8
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