High-throughput target discovery using cell-based genetics

被引：11

作者：

Jackson, RD ^{[1
]}

Harrington, JI ^{[1
]}

机构：

[1] Athersys Inc, Cleveland, OH 44115 USA

来源：

DRUG DISCOVERY TODAY | 2005年 / 10卷 / 01期

关键词：

D O I：

10.1016/S1359-6446(04)03303-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

High-throughput target discovery requires robust disease models and the ability to rapidly survey the genome for function. In the post-genomics era, there has been a strong emphasis placed upon 'gene-to-function' approaches that take advantage of the large amount of gene sequence information now available. Here, we advocate a return to 'function-to-gene' approaches as a first step in target discovery (and validation), followed by hypothesis-driven research to validate new targets identified by their activity in cell-based disease models.

引用

收藏

页码：53 / 60

页数：8

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