Determination of 61 elements in urine samples collected from a non-occupationally exposed UK adult population

被引：117
作者：
Morton, Jackie [1 ]
Tan, Emma [1 ]
Leese, Elizabeth [1 ]
Cocker, John [1 ]
机构：
[1] Hlth & Safety Lab, Buxton SK17 9JN, Derby, England
来源：
TOXICOLOGY LETTERS | 2014年 / 231卷 / 02期
关键词：
Reference values; Elements; ICP-MS; Unexposed; 95th percentiles; Urine; Human biomonitoring; REFERENCE VALUES;
D O I：
10.1016/j.toxlet.2014.08.019
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Background: levels for 61 elements were established in urine samples collected from 132 occupationally unexposed UK adults. In this study all elements were determined by inductively coupled plasma-mass spectrometry, but methods were 'tailored' to the elements; in total six analytical methods were undertaken. For the first time in a UK population 95th percentile values are reported for 19 elements for which there is no available comparison. Repeat urine samples were collected from some individuals and mixed effects modelling was carried out on the data to give an estimation of variation both between individuals and within the same individual. The mixed effects modelling was undertaken on 31 of the 61 elements for which there were more than two thirds of data above the LOQ and variations of between and within individuals are reported. The analysis found that creatinine adjustment of analyte concentrations was found to be beneficial for 22 of the 31 elements and that smokers were found to exhibit significantly higher cadmium but lower boron than non-smokers. For most elements, the data compare well with other published data but higher concentrations were observed in this study for urinary lead, chromium, vanadium and tungsten. (C) 2014 The Authors. Published by Elsevier Ireland Ltd.
引用
收藏
页码：179 / 193
页数：15
相关论文
共 20 条
[11]  
HSE, 1997, 167 HSG
[12]  
Institut fur Arbeitsschutz der Deutschen Gesetzlichen Unfallversicherung, 2012, GESTIS INT LIM VAL
[13]  
Leese E., 2013, J ANAL TOXICOL, P1
[14]   WinBUGS - A Bayesian modelling framework: Concepts, structure, and extensibility [J].
Lunn, DJ ;
Thomas, A ;
Best, N ;
Spiegelhalter, D .
STATISTICS AND COMPUTING, 2000, 10 (04) :325-337
[15]   Concept of the Flemish human biomonitoring programme [J].
Schoeters, Greet ;
Den Hond, Elly ;
Colles, Ann ;
Loots, Ilse ;
Morrens, Bert ;
Keune, Hans ;
Bruckers, Liesbeth ;
Nawrot, Tim ;
Sioen, Isabelle ;
De Coster, Sam ;
Van Larebeke, Nicolas ;
Nelen, Vera ;
Van de Mieroop, Els ;
Vrijens, Jan ;
Croes, Kim ;
Goeyens, Karen ;
Baeyens, Willy .
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH, 2012, 215 (02) :102-108
[16]   The German Human Biomonitoring Commission [J].
Schulz, C. ;
Angerer, J. ;
Ewers, U. ;
Kolossa-Gehring, M. .
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH, 2007, 210 (3-4) :373-382
[17]   Update of the reference and HBM values derived by the German Human Biomonitoring Commission [J].
Schulz, Christine ;
Wilhelm, Michael ;
Heudorf, Ursel ;
Kolossa-Gehring, Marike .
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH, 2011, 215 (01) :26-35
[18]   Twenty-four-hour urinary trace element excretion: reference intervals and interpretive issues [J].
Sieniawska, Christine E. ;
Jung, Lynne C. ;
Olufadi, Rasaq ;
Walker, Valerie .
ANNALS OF CLINICAL BIOCHEMISTRY, 2012, 49 :341-351
[19]   High Urinary Tungsten Concentration Is Associated with Stroke in the National Health and Nutrition Examination Survey 1999-2010 [J].
Tyrrell, Jessica ;
Galloway, Tamara S. ;
Abo-Zaid, Ghada ;
Melzer, David ;
Depledge, Michael H. ;
Osborne, Nicholas J. .
PLOS ONE, 2013, 8 (11)
[20]   Trace element reference values in tissues from inhabitants of the European union. X. A study of 13 elements in blood and urine of a United Kingdom population [J].
White, MA ;
Sabbioni, E .
SCIENCE OF THE TOTAL ENVIRONMENT, 1998, 216 (03) :253-270
12