Impact of IFNL4-ΔG genotype on sustained virologic response in hepatitis C genotype 1 patients treated with direct-acting antivirals

被引：5
|
作者：
Backus, Lisa I. [1 ]
Shahoumian, Troy A. [1 ]
Belperio, Pamela S. [1 ]
Winters, Mark [2 ]
Prokunina-Olsson, Ludmila [3 ]
O'Brien, Thomas R. [3 ]
Holodniy, Mark [2 ,4 ]
机构：
[1] Populat Hlth Serv, Dept Vet Affairs, Palo Alto, CA 94304 USA
[2] Stanford Univ, Div Infect Dis & Geog Med, Stanford, CA 94305 USA
[3] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA
[4] Off Publ Hlth Surveillance & Res, Dept Vet Affairs, Palo Alto, CA 94304 USA
来源：
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2018年 / 92卷 / 01期
基金：
美国国家卫生研究院;
关键词：
IFNL4; SVR; hepatitis C virus; DAA therapy; Veterans; HCV CLEARANCE; VIRUS; IFNL4; ASSOCIATION; INFECTION; RIBAVIRIN; VARIANTS; THERAPY; IL28B;
D O I：
10.1016/j.diagmicrobio.2018.04.004
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
In direct acting antiviral (DAA)-treated HCV genotype 1, the sustained virologic response rate with the Delta G/Delta G genotype of IFNL4 rs368234815 (86.8%) was significantly lower than with Delta G/TT (95.9%, P = 0.03) or TT/IT (98.6%, P = 0.01). The SVR odds ratio for Delta G/Delta G compared to TT/TT was 0.10 (P = 0.03). IFNL4 genotype might predict DAA-response. Published by Elsevier Inc.
引用
收藏
页码：34 / 36
页数：3
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