Emphysematous cholecystitis in a patient with gastrointestinal stromal tumor treated with sunitinib

被引:18
|
作者
de Lima Lopes, Gilberto, Jr.
Rocha Lima, Caio Max
机构
[1] Johns Hopkins Singapore IMC, Singapore 308433, Singapore
[2] Univ Miami, Miller Sch Med, Sylvester Comprehens Canc Ctr, Miami, FL 33152 USA
来源
PHARMACOTHERAPY | 2007年 / 27卷 / 05期
关键词
gastrointestinal stromal tumor; sunitinib; angiogenesis; vascular endothelial growth factor; VEGF; emphysematous cholecystitis;
D O I
10.1592/phco.27.5.775
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
A 50-year-old man had a metastatic gastrointestinal stromal tumor that was refractory to imatinib. He was prescribed a 6-week course of treatment with oral sunitinib 50 mg/day. During the fourth week of his first cycle of treatment with the drug, the patient developed acute-onset, right upper quadrant pain associated with nausea, vomiting, and fever; laboratory tests revealed leukocytosis and mild hyperbilirubinemia. He was diagnosed with acute emphysematous cholecystitis, which was treated with broad-spectrum antibiotics and percutaneous cholecystostomy His symptoms resolved, and he successfully completed his course of therapy with sunitinib. Using the Naranjo adverse drug reaction probability scale, a score of 5 was derived, which indicates that the likelihood was probable that this adverse event was caused by sunitinib.
引用
收藏
页码:775 / 777
页数:3
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