New opportunities with quantification of protein therapeutics by LC-MS

被引:5
作者
Neubert, Hendrik [1 ]
Xu, Keyang [2 ]
机构
[1] Pfizer Inc, 1 Burtt Rd, Andover, MA 01810 USA
[2] Genentech Inc, 1 DNA Way, San Francisco, CA 94080 USA
关键词
bottom-up; digestion; HRMS; immunoaffinity; LC-MS; protein quantification; protein therapeutics;
D O I
10.4155/bio-2018-0151
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:971 / 973
页数:3
相关论文
共 9 条
  • [1] Hybrid assays: the next big thing?
    Booth, Brian P.
    Furmanski, Brian
    [J]. BIOANALYSIS, 2018, 10 (13) : 975 - 977
  • [2] Improving selectivity and sensitivity of protein quantitation by LC-HR-MS/MS: determination of somatropin in rat plasma
    Bults, Peter
    Meints, Marcel
    Sonesson, Anders
    Knutsson, Magnus
    Bischoff, Rainer
    van de Merbel, Nico C.
    [J]. BIOANALYSIS, 2018, 10 (13) : 1009 - 1021
  • [3] Progress in high-sensitivity hybrid LC-MS/MS methods for the bioanalysis of protein drugs and performance tests for their validation
    Duggan, Jeffrey X.
    [J]. BIOANALYSIS, 2018, 10 (13) : 983 - 986
  • [4] Glu-C, an alternative digestive enzyme for the quantitative LC-MS/MS analysis of an IgG-based antibody biotherapeutic
    Hansen, Kjetil
    Szarka, Szabolcs
    Escoffier, Emilie
    Berthet, Amandine
    Venet, Joris
    Collet-Brose, Justine
    Hepburn, Sophie
    Wright, Michael
    Wheller, Robert
    Nelson, Robert
    Kay, Richard G.
    [J]. BIOANALYSIS, 2018, 10 (13) : 997 - 1007
  • [5] Pu J, 2018, BIOANALYSIS, V10, P979, DOI [10.4155/bio-2018-0263, 10.4155/bio-2018-0056]
  • [6] Quantitation of intact monoclonal antibody in biological samples: comparison of different data processing strategies
    Qiu, Xi
    Kang, Lijuan
    Case, Martin
    Weng, Naidong
    Jian, Wenying
    [J]. BIOANALYSIS, 2018, 10 (13) : 1055 - 1067
  • [7] Development of an automated, interference-free, 2D-LC-MS/MS assay for quantification of a therapeutic mAb in human sera
    Sucharski, Filip K.
    Meier, Simon
    Miess, Christian
    Razavi, Morty
    Pope, Matt
    Yip, Richard
    Anderson, N. Leigh
    Pearson, Terry W.
    Warren, Andrew Paul
    Krantz, Carsten
    [J]. BIOANALYSIS, 2018, 10 (13) : 1023 - 1037
  • [8] Top-down LC-MS quantitation of intact denatured and native monoclonal antibodies in biological samples
    Zhang, Liyun
    Vasicek, Lisa A.
    Hsieh, SuChun
    Zhang, Shuli
    Bateman, Kevin P.
    Henion, Jack
    [J]. BIOANALYSIS, 2018, 10 (13) : 1039 - 1054
  • [9] Critical considerations for immunocapture enrichment LC-MS bioanalysis of protein therapeutics and biomarkers
    Zhao, Yue
    Gu, Huidong
    Zheng, Naiyu
    Zeng, Jianing
    [J]. BIOANALYSIS, 2018, 10 (13) : 987 - 995