Proton Pump Inhibitors and Dabigatran Therapy: Impact on Gastric Bleeding and Dabigatran Plasma Levels

被引：18

作者：

Bolek, Tomas ^{[1
]}

Samos, Matej ^{[1
]}

Skornova, Ingrid ^{[2
]}

Galajda, Peter ^{[1
]}

Stasko, Jan ^{[2
]}

Kubisz, Peter ^{[2
]}

Mokan, Marian ^{[1
]}

机构：

[1] Comenius Univ, Jessenius Fac Med Martin, Dept Internal Med 1, Kollarova 2, Martin 03659, Slovakia

[2] Comenius Univ, Jessenius Fac Med Martin, Natl Ctr Hemostasis & Thrombosis, Dept Hematol & Blood Transfus, Martin, Slovakia

来源：

SEMINARS IN THROMBOSIS AND HEMOSTASIS | 2019年 / 45卷 / 08期

关键词：

dabigatran; proton pump inhibitors; atrial fibrillation; gastrointestinal bleeding; dabigatran levels; ATRIAL-FIBRILLATION; ORAL ANTICOAGULANTS; DRUG-INTERACTION; WARFARIN; HOSPITALIZATION; LANSOPRAZOLE; PANTOPRAZOLE; OMEPRAZOLE; ETEXILATE; RISK;

D O I：

10.1055/s-0039-1695735

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Dabigatran etexilate, a direct thrombin inhibitor, is now frequently used for long-term pharmacological prevention of stroke or systemic embolism in patients with atrial fibrillation. However, such long-term dabigatran therapy (DT) significantly increases the risk of upper gastrointestinal (GI) bleeding. This increased risk of gastric bleeds might be reduced with gastroprotective agents, such as proton pump inhibitors (PPIs). PPIs coadministrated with dabigatran reduce the risk of upper GI bleeding in patients on long-term oral DT. Nevertheless, there is heated discussion regarding interactions between PPI and dabigatran that lead to decreases in dabigatran plasma levels. This article reviews up to date data about the risk of gastric bleeding on dabigatran, the impact of PPI on the reduction of gastric bleeding, and the interaction between PPI and dabigatran leading to decreased dabigatran plasma levels.

引用

页码：846 / 850

页数：5

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