Intraoperative Functional Ultrasound Imaging of Human Brain Activity

被引：79
作者：
Imbault, Marion [1 ]
Chauvet, Dorian [2 ,3 ]
Gennisson, Jean-Luc [1 ]
Capelle, Laurent [2 ]
Tanter, Mickael [1 ]
机构：
[1] PSL Res Univ, ESPCI ParisTech, CNRS, Inst Langevin Ondes & Images,UMR 7587,INSERM,U979, 17 Rue Moreau, F-75012 Paris, France
[2] Grp Hosp Pitie Salpetriere, Serv Neurochirurg, Batiment Babinski 47-83 Blvd Hop, F-75013 Paris, France
[3] Fdn Adolphe De Rothschild, Serv Neurochirurg, 29 Rue Manin, F-75019 Paris, France
来源：
SCIENTIFIC REPORTS | 2017年 / 7卷
基金：
欧洲研究理事会;
关键词：
COLUMN-ADDRESSED ARRAYS; MOVING BLOOD-VOLUME; DOPPLER; SURGERY; STIMULATION; TOMOGRAPHY; SIGNALS;
D O I：
10.1038/s41598-017-06474-8
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The functional mapping of brain activity is essential to perform optimal glioma surgery and to minimize the risk of postoperative deficits. We introduce a new, portable neuroimaging modality of the human brain based on functional ultrasound (fUS) for deep functional cortical mapping. Using plane-wave transmissions at an ultrafast frame rate (1 kHz), fUS is performed during surgery to measure transient changes in cerebral blood volume with a high spatiotemporal resolution (250 mu m, 1 ms). fUS identifies, maps and differentiates regions of brain activation during task-evoked cortical responses within the depth of a sulcus in both awake and anaesthetized patients.
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页数：7
相关论文
共 36 条
  • [31] FRACTIONAL MOVING BLOOD-VOLUME - ESTIMATION WITH POWER DOPPLER US
    RUBIN, JM
    ADLER, RS
    FOWLKES, JB
    SPRATT, S
    PALLISTER, JE
    CHEN, JF
    CARSON, PL
    [J]. RADIOLOGY, 1995, 197 (01) : 183 - 190
  • [32] Evaluation of coupling between optical intrinsic signals and neuronal activity in rat somatosensory cortex
    Sheth, S
    Nemoto, M
    Guiou, M
    Walker, M
    Pouratian, N
    Toga, AW
    [J]. NEUROIMAGE, 2003, 19 (03) : 884 - 894
  • [33] THE EFFECTS OF HEMATOCRIT, SHEAR RATE, AND TURBULENCE ON ULTRASONIC DOPPLER SPECTRUM FROM BLOOD
    SHUNG, KK
    CLOUTIER, G
    LIM, CC
    [J]. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 1992, 39 (05) : 462 - 469
  • [34] SCATTERING OF ULTRASOUND BY BLOOD
    SHUNG, KK
    SIGELMANN, RA
    REID, JM
    [J]. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 1976, 23 (06) : 460 - 467
  • [35] Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery
    Yemisci, Muge
    Gursoy-Ozdemir, Yasemin
    Vural, Atay
    Can, Alp
    Topalkara, Kamil
    Dalkara, Turgay
    [J]. NATURE MEDICINE, 2009, 15 (09) : 1031 - U82
  • [36] Yu A, 2010, IEEE T ULTRASON FERR, V57
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