Intraoperative Functional Ultrasound Imaging of Human Brain Activity

被引：78
作者：
Imbault, Marion [1 ]
Chauvet, Dorian [2 ,3 ]
Gennisson, Jean-Luc [1 ]
Capelle, Laurent [2 ]
Tanter, Mickael [1 ]
机构：
[1] PSL Res Univ, ESPCI ParisTech, CNRS, Inst Langevin Ondes & Images,UMR 7587,INSERM,U979, 17 Rue Moreau, F-75012 Paris, France
[2] Grp Hosp Pitie Salpetriere, Serv Neurochirurg, Batiment Babinski 47-83 Blvd Hop, F-75013 Paris, France
[3] Fdn Adolphe De Rothschild, Serv Neurochirurg, 29 Rue Manin, F-75019 Paris, France
来源：
SCIENTIFIC REPORTS | 2017年 / 7卷
基金：
欧洲研究理事会;
关键词：
COLUMN-ADDRESSED ARRAYS; MOVING BLOOD-VOLUME; DOPPLER; SURGERY; STIMULATION; TOMOGRAPHY; SIGNALS;
D O I：
10.1038/s41598-017-06474-8
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The functional mapping of brain activity is essential to perform optimal glioma surgery and to minimize the risk of postoperative deficits. We introduce a new, portable neuroimaging modality of the human brain based on functional ultrasound (fUS) for deep functional cortical mapping. Using plane-wave transmissions at an ultrafast frame rate (1 kHz), fUS is performed during surgery to measure transient changes in cerebral blood volume with a high spatiotemporal resolution (250 mu m, 1 ms). fUS identifies, maps and differentiates regions of brain activation during task-evoked cortical responses within the depth of a sulcus in both awake and anaesthetized patients.
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页数：7
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