Meta-analysis of serum non-high-density lipoprotein cholesterol and risk of coronary heart disease in the general population

被引:19
作者
Liu, Hongtao [1 ]
Deng, Xia [2 ]
Peng, Yudong [3 ]
Zeng, Qiutang [3 ]
Song, Zongren [1 ]
He, Wenping [1 ]
Zhang, Le [1 ]
Gao, Gan [1 ]
Xiao, Ting [1 ]
Yu, Xuedong [1 ]
机构
[1] Guangdong Med Univ, Shenzhen Longhua Dist Cent Hosp, Dept Cardiovasc Med, Longhua Cent Hosp Affiliated, 187 Guanlan Ave, Shenzhen 518110, Guangdong, Peoples R China
[2] Guangdong Med Univ, Shenzhen Longhua Dist Cent Hosp, Pharm Dept, Longhua Cent Hosp Affiliated, Shenzhen 518110, Guangdong, Peoples R China
[3] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Inst Cardiovasc Dis, Wuhan 430022, Hubei, Peoples R China
关键词
Non-high-density lipoprotein cholesterol; Coronary heart disease; Meta-analysis; NON-HDL CHOLESTEROL; CARDIOVASCULAR-DISEASE; JAPANESE; ASSOCIATION; PREDICTION; EVENTS;
D O I
10.1016/j.cca.2017.05.006
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Background: Non-high-density lipoprotein cholesterol (non-HDL-C) has been proposed an independent risk factor for coronary heart disease (CHD). However, the magnitude of this association in the general population varied considerably. Objective: To investigate the association of baseline non-HDL-C level with CHD risk in the general population by conducting a meta-analysis. Methods: A comprehensive literature search was performed in the Pubmed and Embase until January 2017. Prospective observational studies that investigated the association between baseline non-HDL-C level and CHD risk in the general population were included. Pooled hazard ratio (HR) and corresponding 95% confidence interval (CI) were calculated for the highest vs. the lowest non-HDL-C category. Results: Seven articles with 9 independent prospective studies involving 448,732 individuals were included. Meta-analysis showed that individuals with the highest non-HDL-C level at baseline were associated with greater risk of CHD (RR 1.79; 95% CI 1.68-1.91) than those in the lowest non-HDL-C level category. Subgroup analysis suggested that the risk of CHD seemed more pronounced among men (HR 1.98; 95% CI 1.70-2.30) than among women (HR 1.63; 95% CI 1.35-1.96). Conclusions: Higher baseline non-HDL-C level is associated with increased risk of CHD in the general population. This risk seems more pronounced in men than in women. However, gender difference in non-HDL-C level associated with CHD risk should be verified by more well-designed prospective studies.
引用
收藏
页码:23 / 28
页数:6
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