Insulin-like growth factor-I (IGF-I) serum concentrations in healthy children and adolescents: Relationship to level of contamination by DDT-derivative pesticides

被引：25

作者：

Zumbado, Manuel ^{[1
,2
]}

Luzardo, Octavio P. ^{[1
,2
]}

Lara, Pedro C. ^{[2
,3
]}

Alvarez-Leon, Eva E. ^{[4
,5
]}

Losada, Antonio ^{[6
]}

Apolinario, Rosa ^{[2
,7
]}

Serra-Majem, Lluis ^{[2
,8
]}

Boada, Luis D. ^{[1
,2
]}

机构：

[1] Univ Las Palmas Gran Canaria, Dept Clin Sci, Toxicol Unit, Las Palmas Gran Canaria 35080, Spain

[2] ICIC, Las Palmas Gran Canaria 35080, Spain

[3] Univ Las Palmas Gran Canaria, Dept Clin Sci, Radiol Unit, Las Palmas Gran Canaria 35080, Spain

[4] Canary Hlth Serv, Complejo Hosp Insular Mat Infantil, Prevent Med Serv, Las Palmas Gran Canaria 35016, Spain

[5] ICIC, Las Palmas Gran Canaria 35016, Spain

[6] Canary Hlth Serv, Hosp Univ Gen Gran Canaria Dr Negrin, Clin Anal Serv, Las Palmas Gran Canaria 35010, Spain

[7] Univ Las Palmas Gran Canaria, Dept Med & Surg Sci, Las Palmas Gran Canaria 35080, Spain

[8] Univ Las Palmas Gran Canaria, Dept Clin Sci, Prevent Med Unit, Las Palmas Gran Canaria 35080, Spain

来源：

GROWTH HORMONE & IGF RESEARCH | 2010年 / 20卷 / 01期

关键词：

Serum; DDT-derivative pesticides; Children; Adolescents; IGF-I; IGFBP-3; Canary Islands; BINDING PROTEIN-3 IGFBP-3; BREAST-CANCER; HORMONE; EXPOSURE; RISK; SEX; AGE; ASSOCIATIONS; POLLUTANTS; ESTROGENS;

D O I：

10.1016/j.ghir.2009.07.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Context: Serum levels of Insulin-like growth factor I (IGIF-I) play a critical role in children growth and in the pathogenesis of several diseases. In addition, recent Studies suggest that DDT-derivative organochlorine pesticides (OC-DDTs) could influence IGF levels in human beings. Objective and design: Because it has been suggested that IGF-I peak levels at puberty could determine IGF-I levels in adulthood, we developed a cross-sectional study of the potential association between serum levels of OC-DDTs and IGF system in 160 serum samples from young people (81 boys and 79 girls) living in the Canary Islands (Spain). Results: Multivariate tests were used adjusting for confounding variables (age, height, and weight) and stratifying by gender and age: IGF-I serum levels were significantly lower in pre-pubertal male children (6-15 years) who showed detectable Values of p,p'-DDE, and p,p'-DDD than in pre-pubertal male children with undetectable levels of these OC-DDT's-metabolites (p = 0.023 and p = 0.049, respectively). In addition, in this multivariate model, a non-linear dose-response curve was observed between Total DDT body burden (sum of the three DDT-derivatives measured: p,p'-DDT, p,p'-DDE, and p,p'-DDD) and IGF-I in prepubertal male children (6-15 years; p = 0.043). Conclusion: These findings Suggest that OC-DDTs Could modulate the IGF-system in a way that is highly influenced by gender and age. Improvements in our understanding of exogenous determinants of the IGF-system may provide new insights into the role played by environmental contaminants in IGF-related diseases. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：63 / 67

页数：5

共 46 条

[31] Ethinylestradiol and testosterone have divergent effects on circulating IGF system components in adolescents with constitutional tall stature [J].