Role of Vitamin D in Inflammatory Bowel Disease

被引：40

作者：

Limketkai, Berkeley N. ^{[1
,2
]}

Mullin, Gerard E. ^{[2
]}

Limsui, David ^{[1
]}

Parian, Alyssa M. ^{[2
]}

机构：

[1] Stanford Univ, Sch Med, Div Gastroenterol & Hepatol, Stanford, CA 94305 USA

[2] Johns Hopkins Univ, Sch Med, Div Gastroenterol & Hepatol, Baltimore, MD USA

来源：

NUTRITION IN CLINICAL PRACTICE | 2017年 / 32卷 / 03期

关键词：

cholecalciferol; Crohn's disease; ergocalciferol; inflammatory bowel diseases; ulcerative colitis; vitamin D; vitamin D deficiency; REGULATORY T-CELLS; INTESTINAL MUCOSAL LESIONS; BLOOD MONONUCLEAR-CELLS; BONE-MINERAL DENSITY; QUALITY-OF-LIFE; CROHNS-DISEASE; D-RECEPTOR; 1,25-DIHYDROXYVITAMIN D-3; D DEFICIENCY; ULCERATIVE-COLITIS;

D O I：

10.1177/0884533616674492

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Vitamin D is a secosteroid hormone that possesses immunomodulatory properties and has been demonstrated to potentially influence inflammatory bowel disease (IBD) pathogenesis and activity. Epidemiologic data have associated vitamin D deficiency with an increased risk of IBD, hospitalizations, surgery, and loss of response to biologic therapy. Conversely, IBD itself can lead to vitamin D deficiency. This bidirectional relationship between vitamin D and IBD suggests the need for monitoring and repletion of vitamin D, as needed, in the IBD patient. This review discusses the role of vitamin D in IBD and provides practical guidance on vitamin D repletion.

引用

页码：337 / 345

页数：9

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