Potential application of hydrogel to the diagnosis and treatment of multiple sclerosis

被引:5
作者
Liu, Haochuan [1 ]
Chen, Bing [2 ]
Zhu, Qingsan [1 ]
机构
[1] Jilin Univ, China Japan Union Hosp, Dept Orthopaed, Xiantai St 126, Changchun 130031, TX, Peoples R China
[2] Jilin Univ, China Japan Union Hosp, Dept Anesthesiol, Xiantai St 126, Changchun 130031, TX, Peoples R China
基金
中国国家自然科学基金; 中国博士后科学基金;
关键词
Hydrogel; Multiple sclerosis; Biosensor; Cell culture; Cell delivery; STEM-CELL TRANSPLANTATION; DRUG-DELIVERY; DENDRITIC CELLS; PEPTIDE; CLARITY; LESIONS; MODEL; MMP-9; CNS;
D O I
10.1186/s13036-022-00288-7
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system. This disorder may cause progressive and permanent impairment, placing significant physical and psychological strain on sufferers. Each progress in MS therapy marks a significant advancement in neurological research. Hydrogels can serve as a scaffold with high water content, high expansibility, and biocompatibility to improve MS cell proliferation in vitro and therapeutic drug delivery to cells in vivo. Hydrogels may also be utilized as biosensors to detect MS-related proteins. Recent research has employed hydrogels as an adjuvant imaging agent in immunohistochemistry assays. Following an overview of the development and use of hydrogels in MS diagnostic and therapy, this review discussed hydrogel's advantages and future opportunities in the diagnosis and treatment of MS.
引用
收藏
页数:9
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