Potential application of hydrogel to the diagnosis and treatment of multiple sclerosis

被引:5
作者
Liu, Haochuan [1 ]
Chen, Bing [2 ]
Zhu, Qingsan [1 ]
机构
[1] Jilin Univ, China Japan Union Hosp, Dept Orthopaed, Xiantai St 126, Changchun 130031, TX, Peoples R China
[2] Jilin Univ, China Japan Union Hosp, Dept Anesthesiol, Xiantai St 126, Changchun 130031, TX, Peoples R China
基金
中国国家自然科学基金; 中国博士后科学基金;
关键词
Hydrogel; Multiple sclerosis; Biosensor; Cell culture; Cell delivery; STEM-CELL TRANSPLANTATION; DRUG-DELIVERY; DENDRITIC CELLS; PEPTIDE; CLARITY; LESIONS; MODEL; MMP-9; CNS;
D O I
10.1186/s13036-022-00288-7
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system. This disorder may cause progressive and permanent impairment, placing significant physical and psychological strain on sufferers. Each progress in MS therapy marks a significant advancement in neurological research. Hydrogels can serve as a scaffold with high water content, high expansibility, and biocompatibility to improve MS cell proliferation in vitro and therapeutic drug delivery to cells in vivo. Hydrogels may also be utilized as biosensors to detect MS-related proteins. Recent research has employed hydrogels as an adjuvant imaging agent in immunohistochemistry assays. Following an overview of the development and use of hydrogels in MS diagnostic and therapy, this review discussed hydrogel's advantages and future opportunities in the diagnosis and treatment of MS.
引用
收藏
页数:9
相关论文
共 109 条
[1]   Aptamer-functionalized hydrogels: An emerging class of biomaterials for protein delivery, cell capture, regenerative medicine, and molecular biosensing [J].
Abune, Lidya ;
Davis, Brandon ;
Wang, Yong .
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 2021, 13 (06)
[2]   Biomaterials in treatment of Alzheimer's disease [J].
Agrawal, Mukta ;
Prathyusha, Eluri ;
Ahmed, Hafiz ;
Dubey, Sunil Kumar ;
Kesharwani, Prashant ;
Singhvi, Gautam ;
Naidu, V. G. M. ;
Alexander, Amit .
NEUROCHEMISTRY INTERNATIONAL, 2021, 145
[3]   Peptide Cross-Linked Poly(2-oxazoline) as a Sensor Material for the Detection of Proteases with a Quartz Crystal Microbalance [J].
Ahmad, Norlaily ;
Colak, Burcu ;
Gibbs, Martin John ;
Zhang, De-Wen ;
Gautrot, Julien E. ;
Watkinson, Michael ;
Becer, C. Remzi ;
Krause, Steffi .
BIOMACROMOLECULES, 2019, 20 (07) :2506-2514
[4]   Hydrogel-Based Nanocomposites and Mesenchymal Stem Cells: A Promising Synergistic Strategy for Neurodegenerative Disorders Therapy [J].
Albani, Diego ;
Gloria, Antonio ;
Giordano, Carmen ;
Rodilossi, Serena ;
Russo, Teresa ;
D'Amora, Ugo ;
Tunesi, Marta ;
Cigada, Alberto ;
Ambrosio, Luigi ;
Forloni, Gianluigi .
SCIENTIFIC WORLD JOURNAL, 2013,
[5]   25th Anniversary Article: Rational Design and Applications of Hydrogels in Regenerative Medicine [J].
Annabi, Nasim ;
Tamayol, Ali ;
Uquillas, Jorge Alfredo ;
Akbari, Mohsen ;
Bertassoni, Luiz E. ;
Cha, Chaenyung ;
Camci-Unal, Gulden ;
Dokmeci, Mehmet R. ;
Peppas, Nicholas A. ;
Khademhosseini, Ali .
ADVANCED MATERIALS, 2014, 26 (01) :85-124
[6]   End of the road for daclizumab in multiple sclerosis [J].
不详 .
LANCET, 2018, 391 (10125) :1000-1000
[7]   How Microgels Can Improve the Impact of Organ-on-Chip and Microfluidic Devices for 3D Culture: Compartmentalization, Single Cell Encapsulation and Control on Cell Fate [J].
Argentiere, Simona ;
Siciliano, Pietro Aleardo ;
Blasi, Laura .
POLYMERS, 2021, 13 (19)
[8]   Immunoablation and autologous haemopoietic stem-cell transplantation for aggressive multiple sclerosis: a multicentre single-group phase 2 trial [J].
Atkins, Harold L. ;
Bowman, Marjorie ;
Allan, David ;
Anstee, Grizel ;
Arnold, Douglas L. ;
Bar-Or, Amit ;
Bence-Bruckler, Isabelle ;
Birch, Paul ;
Bredeson, Christopher ;
Chen, Jacqueline ;
Fergusson, Dean ;
Halpenny, Mike ;
Hamelin, Linda ;
Huebsch, Lothar ;
Hutton, Brian ;
Laneuville, Pierre ;
Lapierre, Yves ;
Lee, Hyunwoo ;
Martin, Lisa ;
McDiarmid, Sheryl ;
O'Connor, Paul ;
Ramsay, Timothy ;
Sabloff, Mitchell ;
Walker, Lisa ;
Freedman, Mark S. .
LANCET, 2016, 388 (10044) :576-585
[9]   Serum MMP-2 and MMP-9 are elevated in different multiple sclerosis subtypes [J].
Avolio, C ;
Ruggieri, M ;
Giuliani, F ;
Liuzzi, GM ;
Leante, R ;
Riccio, P ;
Livrea, P ;
Trojano, M .
JOURNAL OF NEUROIMMUNOLOGY, 2003, 136 (1-2) :46-53
[10]   A 3-Dimensional Hydrogel Model of Multiple Sclerosis Brain Lesions Reveals Insights into Re-Myelination [J].
Baisiwala, Shivani ;
Moreno, Monica A. ;
Wang, Christine ;
Rogan, Heather A. W. ;
Tsai, Hsing-Chuan ;
Yang, Fan ;
Han, May H. .
JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING, 2017, 7 (09) :868-875