Overexpression of proteasomal activator PA28α serves as a prognostic factor in oral squamous cell carcinoma

被引：19

作者：

Feng, Xiaodong ^{[1
]}

Jiang, Yuchen ^{[1
]}

Xie, Liang ^{[1
]}

Jiang, Lu ^{[1
]}

Li, Jing ^{[1
]}

Sun, Chongkui ^{[1
]}

Xu, Hao ^{[1
,2
,3
]}

Wang, Ruinan ^{[1
]}

Zhou, Min ^{[1
]}

Zhou, Yu ^{[1
]}

Dan, Hongxia ^{[1
]}

Wang, Zhiyong ^{[1
]}

Ji, Ning ^{[1
]}

Deng, Peng ^{[1
]}

Liao, Ga ^{[1
]}

Geng, Ning ^{[1
]}

Wang, Yun ^{[1
]}

Zhang, Dunfang ^{[1
]}

Lin, Yunfeng ^{[1
]}

Ye, Ling ^{[1
]}

Liang, Xinhua ^{[1
]}

Li, Longjiang ^{[1
]}

Luo, Gang ^{[5
]}

Feng, Mingye ^{[1
]}

Fang, Juan ^{[4
]}

Zeng, Xin ^{[1
]}

Wang, Zhi ^{[1
,4
]}

Chen, Qianming ^{[1
]}

机构：

[1] Sichuan Univ, West China Coll Stomatol, State Key Lab Oral Dis, 14,Sec 3,Renminnan Rd, Chengdu 610041, Sichuan, Peoples R China

[2] Sichuan Univ, West China Hosp, West China Med Sch, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China

[3] Sichuan Univ, West China Hosp, West China Med Sch, Ctr Canc, Chengdu 610041, Sichuan, Peoples R China

[4] Sun Yat Sen Univ, Guanghua Sch Stomatol, Stomatol Hosp, Guangdong Prov Key Lab Oral Dis, Guangzhou 510275, Guangdong, Peoples R China

[5] Guangzhou Med Univ, Stomatol Hosp, Guangzhou Inst Oral Dis, Key Lab Oral Med, Guangzhou, Peoples R China

来源：

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH | 2016年 / 35卷

基金：

中国国家自然科学基金;

关键词：

PA28; alpha; OSCC; Prognosis; Recurrence; Overall survival; REG-GAMMA-PROTEASOME; ANTIGEN PRESENTATION; CLASS-I; 20S PROTEASOME; CANCER CELLS; EXPRESSION; PATHWAY; PA28; GENE; PA28-BETA;

D O I：

10.1186/s13046-016-0309-z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Despite recent advances in oral squamous cell carcinoma (OSCC) diagnosis and therapy, disease recurrence remains common and is strongly associated with mortality. It is therefore critical to identify new targets for both treatment and diagnostic purposes. We aimed at investigating the role of PA28 alpha, a proteasomal activator in OSCC. Methods: The expression of PA28 alpha was examined in a panel of OSCC cell lines and tissues, associated with oncomine analysis. In a large OSCC patient cohort, the prognostic value of PA28 alpha expression was evaluated. Primary clinical end points were recurrence-free and overall survival rate. Functional involvement of PA28 alpha in OSCC was examined in both in vitro and in vivo models upon specific siRNA knockdown. Results: PA28 alpha was found to be overexpressed in OSCC cell lines and tumor tissues. High expression of PA28 alpha was significantly associated with recurrence and poorer overall survival. Specific knockdown of PA28 alpha inhibited OSCC cell proliferation, migration, invasion in vitro and reduced the growth of OSCC xenografts in vivo. Multivariate Cox regression analyses revealed PA28 alpha as independent prognostic predictors. Conclusions: These results suggest that PA28 alpha is involved in OSCC oncogenesis and may serve as a potential prognostic factor.

引用

页数：12

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