4-aryldihydropyrimidines via the Biginelli condensation: Aza-analogs of nifedipine-type calcium channel modulators

被引：176
作者：
Kappe, CO [1 ]
机构：
[1] Graz Univ, Inst Organ Chem, A-8010 Graz, Austria
来源：
MOLECULES | 1998年 / 3卷 / 01期
关键词：
Biginelli reaction; dihydropyridines; dihydropyrimidines; calcium channel modulators;
D O I：
10.3390/30100001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent results from the author's laboratory in the area of dihydropyrimidine chemistry are summarized.
引用
收藏
页码：1 / 9
页数：9
相关论文
共 87 条
[1]  
Alajarin R, 1994, Bioorg Med Chem, V2, P323, DOI 10.1016/S0968-0896(00)82188-4
[2]   SYNTHESIS OF UNSYMMETRICALLY SUBSTITUTED 1,4-DIHYDROPYRIDINES AND ANALOGOUS CALCIUM-ANTAGONISTS BY MICROWAVE-HEATING [J].
ALAJARIN, R ;
JORDAN, P ;
VAQUERO, JJ ;
ALVAREZBUILLA, J .
SYNTHESIS-STUTTGART, 1995, (04) :389-391
[3]  
ATWAL KS, 1987, HETEROCYCLES, V26, P1189
[4]   DIHYDROPYRIMIDINE CALCIUM-CHANNEL BLOCKERS .3. 3-CARBAMOYL-4-ARYL-1,2,3,4-TETRAHYDRO-6-METHYL-5-PYRIMIDINECARBOXYLIC ACID-ESTERS AS ORALLY EFFECTIVE ANTIHYPERTENSIVE AGENTS [J].
ATWAL, KS ;
SWANSON, BN ;
UNGER, SE ;
FLOYD, DM ;
MORELAND, S ;
HEDBERG, A ;
OREILLY, BC .
JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (02) :806-811
[5]   DIHYDROPYRIMIDINE CALCIUM-CHANNEL BLOCKERS - 2-HETEROSUBSTITUTED 4-ARYL-1,4-DIHYDRO-6-METHYL-5-PYRIMIDINECARBOXYLIC ACID-ESTERS AS POTENT MIMICS OF DIHYDROPYRIDINES [J].
ATWAL, KS ;
ROVNYAK, GC ;
SCHWARTZ, J ;
MORELAND, S ;
HEDBERG, A ;
GOUGOUTAS, JZ ;
MALLEY, MF ;
FLOYD, DM .
JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (05) :1510-1515
[6]   DIHYDROPYRIMIDINE CALCIUM-CHANNEL BLOCKERS .2. 3-SUBSTITUTED-4-ARYL-1,4-DIHYDRO-6-METHYL-5-PYRIMIDINECARBOXYLIC ACID-ESTERS AS POTENT MIMICS OF DIHYDROPYRIDINES [J].
ATWAL, KS ;
ROVNYAK, GC ;
KIMBALL, SD ;
FLOYD, DM ;
MORELAND, S ;
SWANSON, BN ;
GOUGOUTAS, JZ ;
SCHWARTZ, J ;
SMILLIE, KM ;
MALLEY, MF .
JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (09) :2629-2635
[7]   SUBSTITUTED 1,4-DIHYDROPYRIMIDINES .3. SYNTHESIS OF SELECTIVELY FUNCTIONALIZED 2-HETERO-1,4-DIHYDROPYRIMIDINES [J].
ATWAL, KS ;
ROVNYAK, GC ;
OREILLY, BC ;
SCHWARTZ, J .
JOURNAL OF ORGANIC CHEMISTRY, 1989, 54 (25) :5898-5907
[8]  
AUGUSTO O, 1982, J BIOL CHEM, V257, P1288
[9]  
Biginelli P., 1893, GAZZ CHIM ITAL, V23, P360
[10]  
BIKKER JA, 1992, CAN J CHEM, V70, P2249
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