Hyrtinadines C and D, New Azepinoindole-Type Alkaloids from a Marine Sponge Hyrtios sp.

被引：22

作者：

Kubota, Takaaki ^{[1
,2
]}

Nakamura, Kenta ^{[2
]}

Sakai, Kanae ^{[3
]}

Fromont, Jane ^{[4
]}

Gonoi, Tohru ^{[3
]}

Kobayashi, Jun'ichi ^{[2
]}

机构：

[1] Showa Pharmaceut Univ, 3-3165 Higashi Tamagawagakuen, Machida, Tokyo 1948543, Japan

[2] Hokkaido Univ, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan

[3] Chiba Univ, Med Mycol Res Ctr, Chiba 2600856, Japan

[4] Western Australian Museum, Locked Bag 49, Welshpool Dc, WA 6986, Australia

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2016年 / 64卷 / 07期

关键词：

marine sponge; Hyrtios sp; bisindole; azepinoindole; hyrtinadine; antimicrobial activity; INDOLE ALKALOIDS; CLAVICIPITIC ACID; ERGOT ALKALOIDS; BIOSYNTHESIS; HYRTIMOMINES;

D O I：

10.1248/cpb.c16-00201

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

New bisindole alkaloids, hyrtinadines C (1) and D (2), have been isolated from an Okinawan marine sponge Hyrtios sp. The structures of hyrtinadines C (1) and D (2) were elucidated based on analyses of the spectral data. Hyrtinadines C (1) and D (2) were the relatively rare alkaloids possessing a 3,4-fused azepinoindole skeleton. Hyrtinadines C (1) and D (2) showed antimicrobial activity.

引用

页码：975 / 978

页数：4

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