Xanthine oxidoreductase catalyses the reduction of nitrates and nitrite to nitric oxide under hypoxic conditions

被引：392

作者：

Millar, TM

Stevens, CR ^{[1
]}

Benjamin, N

Eisenthal, R

Harrison, R

Blake, DR

机构：

[1] Univ Bath, Dept Postgrad Med, Bone & Joint Res Grp, Bath BA2 7AY, Avon, England

[2] Univ Bath, Dept Biol & Biochem, Bath BA2 7AY, Avon, England

[3] St Bartholomews & Royal London Sch Med & Dent, London EC1M 6BQ, England

来源：

FEBS LETTERS | 1998年 / 427卷 / 02期

关键词：

xanthine oxidoreductase; nitric oxide; nitrate; nitrite;

D O I：

10.1016/S0014-5793(98)00430-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Xanthine oxidoreductase (XOR) catalyses the reduction of the therapeutic organic nitrate, nitroglycerin (glyceryl trinitrate, GTN), as well as inorganic nitrate and nitrite, to nitric oxide (NO) under hypoxic conditions in the presence of NADH. Generation of nitric oxide is not detectable under normoxic conditions and is inhibited by the molybdenum site-specific inhibitors, oxypurinol and (-)BOF 4272, These enzymic reactions provide a mechanism for generation of NO under hypoxic conditions where nitric oxide synthase does not function, suggesting a vasodilatory role in ischaemia. (C) 1998 Federation of European Biochemical Societies.

引用

页码：225 / 228

页数：4

共 38 条

[1] Regulation of endothelial nitric-oxide synthase during hypoxia [J].