Asymmetric catalysis in direct nitromethane-free Henry reactions

被引：40

作者：

Dong, Lin ^{[1
]}

Chen, Fen-Er ^{[1
,2
]}

机构：

[1] Sichuan Univ, West China Sch Pharm, Res Ctr Drug Precis Ind Technol, Chengdu 610041, Peoples R China

[2] Fudan Univ, Dept Chem, Engn Ctr Catalysis & Synth Chiral Mol, Shanghai 200433, Peoples R China

来源：

RSC ADVANCES | 2020年 / 10卷 / 04期

关键词：

SELECTIVE NITROALDOL REACTION; CHIRAL LANTHANIDE COMPLEXES; CU-II; ELECTROCATALYTIC REDUCTION; COORDINATION CHEMISTRY; ALKYLATION REACTIONS; ALPHA-KETOESTERS; COPPER; EFFICIENT; ALDEHYDES;

D O I：

10.1039/c9ra10263a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A great number of reports have described asymmetric catalytic Henry reactions using nitromethanes as pronucleophiles, but far more challenging is diastereoselective catalytic Henry reactions using substituted higher nitroalkanes instead of nitromethane to generate chiral beta-nitro alcohol scaffolds with four adjacent stereogenic centers in a one-pot operation. This review summarizes the current state and applications of such reactions involving complex nitroalkane coupling with various carbonyl compounds for resolving double chiral centers with high enantio- and diastereoselectivities.

引用

页码：2313 / 2326

页数：14

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