Synthesis of cinnamoyl glucoside derivatives and their antiproliferation activities against murine melanoma B16-F10 cell line

被引：1

作者：

Shu, Penghua ^{[1
]}

Yu, Mengzhu ^{[1
]}

Li, Yamin ^{[1
]}

Luo, Yuehui ^{[1
]}

Liu, Hao ^{[1
]}

Zhu, Huiqing ^{[1
]}

Zhang, Jialong ^{[1
]}

Zhang, Lingxiang ^{[1
]}

Wei, Xialan ^{[2
]}

Xiao, Fugang ^{[1
]}

机构：

[1] Xuchang Univ, Food & Pharm Coll, 88 Bayi Rd, Xuchang, Peoples R China

[2] Xuchang Univ, Sch Informat Engn, Xuchang, Peoples R China

来源：

CARBOHYDRATE RESEARCH | 2021年 / 504卷

基金：

中国国家自然科学基金;

关键词：

Cinnamoyl glucoside; Glycosylation; Dechloroacetylation; Antiproliferation; Melanoma; ANTIOXIDANT; PRODUCTS; FRUITS; ACID;

D O I：

10.1016/j.carres.2021.108332

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Twelve cinnamoyl glucoside derivatives were prepared by glycosylation of glucosyl trichloroacetimidate and cinnamic acid derivatives, followed by dechloroacetylation with a pyridine/H2O mixture. Their structures were characterized by 1H and 13C NMR, as well as mass analysis. All the products were tested for their antiproliferation activities against murine melanoma B16-F10 cell line. Compounds 4e-4j were able to inhibit the proliferation of murine melanoma B16-F10 cell line with IC50 values of 17.38 +/- 0.07, 9.87 +/- 0.09, 9.69 +/- 0.12, 29.42 +/- 0.04, 32.95 +/- 0.08, 25.68 +/- 0.09 isM, respectively.

引用

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