Synthesis and characterization of Zn0.4Co0.6Fe2O4 superparamagnetic nanoparticles as a promising agent against proliferation of colorectal cancer cells

被引:5
作者
Sunil, K. C. [1 ]
Utsav, Sen [2 ]
Nairy, Rajesha K. [3 ]
Chethan, G. [1 ]
Shenoy, Sudheer P. [2 ]
Mustak, Mohammed S. [4 ]
Yerol, Narayana [1 ]
机构
[1] Mangalore Univ, Dept Phys, Mangalore 574199, Karnataka, India
[2] Yenepoya Deemed Univ, Yenepoya Res Ctr, Stem Cells & Regenerat Med Ctr, Mangalore 575018, India
[3] PC Jabin Sci Coll, Dept Phys, Hubballi 580031, India
[4] Mangalore Univ, Dept Appl Zool, Mangalore 574199, India
关键词
Superparamagnetic nanoparticles; Hydrothermal method; Cytotoxicity; Anticancer; Radiosensitization; Colorectal cancer cells; IRON-OXIDE NANOPARTICLES; GREEN SYNTHESIS; SILVER NANOPARTICLES; EFFICIENT REMOVAL; TOXICITY; COMPOSITE; EXCHANGE; EXTRACT; HYBRID;
D O I
10.1016/j.ceramint.2021.03.248
中图分类号
TQ174 [陶瓷工业]; TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Superparamagnetic nanoparticles are being used in cancer therapy as agents of MRI contrasting, drug delivery, and hyperthermia therapy. Their radiosensitization ability is less explored in comparison with gold and other high - Z nanoparticles. Herein, we report the radiotherapy application of Zn0.4Co0.6Fe2O4 superparamagnetic nanoparticles against HT-29 colorectal cancer cells. The nanoparticles were synthesized by the hydrothermal method and they were characterized using XRD, VSM, FTIR, DLS, FE-SEM, and XPS techniques. The nanoparticles have spherical morphology with a cubic spinel structure. The surface of the nanoparticles contains hydroxyl and carbonyl functional groups. The hydrodynamic mean size of the nanoparticles is 55.2 nm with a moderate zeta potential of 29.11 mV. The nanoparticles are superparamagnetic with a good saturation magnetization value of 73 emu/g. The cationic distribution study showed that the tetrahedral crystal positions are occupied by Co2+ and Fe3+ cations whereas the octahedral positions are occupied by Zn2+, Co2+, and Fe3+ with Fe3+ being the most. The cytotoxicity was investigated by MTT assay. The anticancer and radiosensitization ability of the nanoparticles was assessed by colony forming assay. The IC50 obtained from the cytotoxicity study is 100 mu g/mL. The anticancer study showed 43% proliferation inhibition at 100 mu g/mL. The combination of 2 Gy and nanoparticles resulted in more damage on colorectal cancer cells than 4 Gy alone in the radiosensitization study. The present investigation suggests that Zn0.4Co0.6Fe2O4 superparamagnetic nanoparticles are potential candidates to enhance the efficacy of radiotherapy in the case of colorectal cancer.
引用
收藏
页码:19026 / 19035
页数:10
相关论文
共 45 条
[21]   Polyvinylpyrrolidone Loaded-MnZnFe2O4Magnetic Nanocomposites Induce Apoptosis in Cancer Cells Through Mitochondrial Damage and P53Pathway [J].
Kareem, Sahira Hassan ;
Naji, Amel Muhson ;
Taqi, Zainab J. ;
Jabir, Majid S. .
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS, 2020, 30 (12) :5009-5023
[22]   Mechanisms of nanoparticle radiosensitization [J].
Kempson, Ivan .
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 2021, 13 (01)
[23]   Nanoparticle-Based Radiosensitization [J].
Kempson, Ivan .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (08)
[24]   Synthesis, Characterization and Evaluation of Anti-bacterial, Anti-parasitic and Anti-cancer Activities of Aluminum-Doped Zinc Oxide Nanoparticles [J].
Khashan, Khawla S. ;
Sulaiman, Ghassan M. ;
Hussain, Sura A. ;
Marzoog, Thorria R. ;
Jabir, Majid S. .
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS, 2020, 30 (09) :3677-3693
[25]   The effect of laser energy on the properties of carbon nanotube-iron oxide nanoparticles composite prepared via pulsed laser ablation in liquid [J].
Khashan, Khawla S. ;
Sulaiman, Ghassan M. ;
Mahdi, Rafal ;
Kadhim, Ali .
MATERIALS RESEARCH EXPRESS, 2018, 5 (10)
[26]   Radiation dose rate affects the radiosensitization of MCF-7 and HeLa cell lines to X-rays induced by dextran-coated iron oxide nanoparticles [J].
Khoshgard, Karim ;
Kiani, Parvaneh ;
Haghparast, Abbas ;
Hosseinzadeh, Leila ;
Eivazi, Mohammad Taghi .
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 2017, 93 (08) :757-763
[27]   Self-Assembled and One-Step Synthesis of Interconnected 3D Network of Fe3O4/Reduced Graphene Oxide Nanosheets Hybrid for High-Performance Supercapacitor Electrode [J].
Kumar, Rajesh ;
Singh, Rajesh K. ;
Vaz, Alfredo R. ;
Savu, Raluca ;
Moshkalev, Stanislav A. .
ACS APPLIED MATERIALS & INTERFACES, 2017, 9 (10) :8880-8890
[28]  
Lee JH, 2011, NAT NANOTECHNOL, V6, P418, DOI [10.1038/nnano.2011.95, 10.1038/NNANO.2011.95]
[29]   Facile microwave-assisted green synthesis of Ag-ZnFe2O4@rGO nanocomposites for efficient removal of organic dyes under UV- and visible-light irradiation [J].
Mady, Amr Hussein ;
Baynosa, Marjorie Lara ;
Tuma, Dirk ;
Shim, Jae-Jin .
APPLIED CATALYSIS B-ENVIRONMENTAL, 2017, 203 :416-427
[30]   ZnFe2O4 nanoparticles as radiosensitizers in radiotherapy of human prostate cancer cells [J].
Meidanchi, Alireza ;
Akhavan, Omid ;
Khoei, Samideh ;
Shokri, Ali A. ;
Hajikarimi, Zahra ;
Khansari, Nakisa .
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2015, 46 :394-399