Nickel-Catalyzed Reductive Cross-Coupling of (Hetero)aryl Halides with 2-Chloro-1,1-difluoroethane: Facile Access to 2,2-Difluoroethylated Aromatics

被引：6

作者：

Diao, Zhengzhen ^{[1
]}

Feng, Yu ^{[1
]}

Zhang, Jida ^{[1
]}

Wang, Xin ^{[2
]}

Li, Hansheng ^{[2
]}

Ding, Chen ^{[2
]}

Zhou, Zhen ^{[1
]}

Li, Xinjin ^{[1
,3
]}

机构：

[1] Shandong Univ Technol, Sch Chem & Chem Engn, 266 West Xincun Rd, Zibo 255000, Peoples R China

[2] Dongyue Fluorosilicone Technol Grp, State Key Lab Fluorinated Funct Membrane Mat, Zibo 256400, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 11卷 / 06期

基金：

中国国家自然科学基金;

关键词：

aryl halides; 2; 2-difluoroethylation; fluorine; nickel; reductive coupling; BACE1; INHIBITORS; ALKYL-HALIDES; DIFLUOROMETHYLATION; FLUORINE; BROMIDES; MILD; 2,2-DICHLORO-1,1,1-TRIFLUOROETHANE; PHARMACEUTICALS; ALDEHYDES; CHLORIDES;

D O I：

10.1002/ajoc.202200169

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mild and efficient nickel-catalyzed 2,2-difluoroethylation of (hetero)aryl halides with readily available 2-chloro-1,1-difluoroethane has been developed. The reductive cross-coupling reaction is synthetically simple and exhibits good functional group tolerance. This approach provides a facile access to synthesize 2,2-difluoroethylated molecules for drug discovery.

引用

页数：5

共 63 条

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