Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business

被引：241
作者：
Wedekind, JE
Dance, GSC
Sowden, MP
Smith, HC
机构：
[1] Univ Rochester, Sch Med & Dent, Dept Biochem & Biophys, Rochester, NY 14623 USA
[2] Univ Cambridge, Dept Haematol, Cambridge, England
来源：
TRENDS IN GENETICS | 2003年 / 19卷 / 04期
关键词：
D O I：
10.1016/S0168-9525(03)00054-4
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Alteration of mRNA sequence through base modification mRNA editing frequently generates protein diversity. Several proteins have been identified as being similar to C-to-U mRNA editing enzymes based on their structural domains and the occurrence of a catalytic domain characteristic of cytidine deaminases. In light of the hypothesis that these proteins might represent novel mRNA editing systems that could affect proteome diversity, we consider their structure, expression and relevance to biomedically significant processes or pathologies.
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收藏
页码：207 / 216
页数：10
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