Does the Histamine H4 Receptor Have a Pro- or Anti-Inflammatory Role in Murine Bronchial Asthma?

被引：33
作者：
Neumann, Detlef [1 ]
Beermann, Silke [1 ]
Seifert, Roland [1 ]
机构：
[1] Hannover Med Sch, Inst Pharmacol, DE-30625 Hannover, Germany
来源：
PHARMACOLOGY | 2010年 / 85卷 / 04期
关键词：
Pro-inflammatory role; Anti-inflammatory role; Histamine H-4 receptor; Bronchial asthma; ALLERGIC AIRWAY INFLAMMATION; MAST-CELLS; PHARMACOLOGICAL CHARACTERIZATION; NEUTROPHIL RECRUITMENT; BONE-MARROW; T-CELLS; MICE; HYPERRESPONSIVENESS; ACTIVATION; RESPONSES;
D O I：
10.1159/000285088
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The histamine H-4 receptor is expressed preferentially on immune cells, indicating a possible role of the H-4 receptor in inflammation. Studies of inflammation in several animal models point to a pro-inflammatory function of the H-4 receptor. However, studies on experimental murine bronchial asthma yielded conflicting results, a fact which is neglected in most H-4 receptor publications. Therefore, the present review critically analyzes available data on the role of the H-4 receptor in the murine bronchial asthma model. Copyright (C) 2010 S. Karger AG, Basel
引用
收藏
页码：217 / 223
页数：7
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