Impact of Systemic Inflammation on the Progression of Gestational Diabetes Mellitus

被引：118

作者：

Lekva, Tove ^{[1
,2
]}

Norwitz, Errol R. ^{[2
,3
,4
]}

Aukrust, Pal ^{[1
,5
,6
]}

Ueland, Thor ^{[1
,5
]}

机构：

[1] Oslo Univ Hosp, Rikshosp, Internal Med Res Inst, Sognsvannsveien 20, N-0027 Oslo, Norway

[2] Tufts Med Ctr, Mother Infant Res Inst, 800 Washington St, Boston, MA 02116 USA

[3] Tufts Med Ctr, Dept Obstet & Gynecol, Boston, MA 02116 USA

[4] Tufts Univ, Sch Med, Boston, MA 02111 USA

[5] Univ Oslo, Fac Med, Oslo, Norway

[6] Oslo Univ Hosp, Rikshosp, Sect Clin Immunol & Infect Dis, N-0450 Oslo, Norway

来源：

CURRENT DIABETES REPORTS | 2016年 / 16卷 / 04期

关键词：

GDM; Systemic inflammation; Adipose tissue; Placenta; NECROSIS-FACTOR-ALPHA; C-REACTIVE PROTEIN; MATERNAL INSULIN-RESISTANCE; LONG PENTRAXIN PTX3; TOLL-LIKE RECEPTORS; REGULATORY T-CELLS; TNF-ALPHA; ADIPOSE-TISSUE; ANTHROPOMETRIC PARAMETERS; CARDIOVASCULAR-DISEASE;

D O I：

10.1007/s11892-016-0715-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

With increasing rates of obesity and new diagnostic criteria for gestational diabetes mellitus (GDM), the overall prevalence of GDM is increasing worldwide. Women with GDM have an increased risk of maternal and fetal complications during pregnancy as well as long-term risks including higher prevalence of type 2 diabetes mellitus and cardiovascular disease. In recent years, the role of immune activation and inflammation in the pathogenesis of GDM has gained increasing attention. This monograph explores the current state of the literature as regards the expression of markers of inflammation in the maternal circulation, placenta, and adipose tissue of women with GDM.

引用

页码：1 / 11

页数：11

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