Subtypes and Mimics of Sepsis

被引：36
作者：
Kellum, John A. [1 ,2 ,5 ]
Formeck, Cassandra L. [1 ,3 ,4 ]
Kernan, Kate F. [1 ,2 ,4 ]
Gomez, Hernando [1 ,2 ]
Carcillo, Joseph A. [1 ,2 ,4 ]
机构：
[1] Univ Pittsburgh, Ctr Crit Care Nephrol, Pittsburgh, PA USA
[2] Univ Pittsburgh, Sch Med, Dept Crit Care Med, Pittsburgh, PA USA
[3] Univ Pittsburgh Sch Med, Dept Pediat, Div Nephrol, Pittsburgh, PA USA
[4] UPMC Childrens Hosp Pittsburgh, Pittsburgh, PA USA
[5] Ctr Crit Care Nephrol, 3347 Forbes Ave,Suite 220, Pittsburgh, PA USA
来源：
CRITICAL CARE CLINICS | 2022年 / 38卷 / 02期
关键词：
Endotoxin; Endotoxemia; Polymyxin B; Blood purification; Macrophage activation syndrome; Atypical hemolytic uremic syndrome; cells; DAMPs; comprising histones; chromosomal DNA; mitochondrial DNA; nucleo-; MACROPHAGE ACTIVATION SYNDROME; POLYMYXIN-B HEMOPERFUSION; MULTIPLE ORGAN FAILURE; GRAM-NEGATIVE SEPSIS; SEPTIC SHOCK; HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS; GENOME-WIDE; PHASE-III; ENDOTOXIN; MORTALITY;
D O I：
10.1016/j.ccc.2021.11.013
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
center dot Inflammation is central to many acute conditions, ranging from infection to sterile tissue injury to rheumatic diseases and to drug/toxin reactions. These conditions easily can be confused with one another. center dot Sepsis is extremely heterogenous at both the clinical and molecular levels. Emerging evidence points to various subphenotypes with divergent pathophysiology. center dot Macrophage activation syndrome is a life-threatening complication of systemic inflammatory disorders, most commonly systemic juvenile idiopathic arthritis, adult-onset Still disease, and systemic lupus erythematosus. center dot Atypical hemolytic uremic syndrome is associated with genetic or acquired disorders that lead to dysregulation of the complement system and thrombotic microangiopathy, resulting in multiple organ failure.
引用
收藏
页码：195 / 211
页数：17
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