Treatment of diabetic kidney disease: current and future targets

被引：27
作者：
Kim, Mi-Kyung [1 ]
机构：
[1] Keimyung Univ, Sch Med, Div Endocrinol & Metab, Dept Internal Med, 56 Dalseong Ro, Daegu 41931, South Korea
来源：
KOREAN JOURNAL OF INTERNAL MEDICINE | 2017年 / 32卷 / 04期
基金：
新加坡国家研究基金会;
关键词：
Diabetes; Kidney; Therapeutics; DIPEPTIDYL PEPTIDASE-4 INHIBITOR; BLOOD-PRESSURE; MICROVASCULAR COMPLICATIONS; DPP-4; INHIBITION; DOUBLE-BLIND; RISK-FACTORS; SRC KINASE; ADD-ON; AUTOPHAGY; NEPHROPATHY;
D O I：
10.3904/kjim.2016.219
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease in Korea and worldwide, and is a risk factor for the development of cardiovascular complications. The conventional treatments for DKD are control of blood glucose and blood pressure levels by inhibiting the renin-angiotensin system. However, the prevalence of DKD continues to increase and additional therapies are required to prevent or ameliorate the condition. Many drugs have been, or are being, developed to target the molecular mechanisms in play in DKD. This review focuses on DVD treatment, considering current and emerging therapeutic targets and the clinical trial-based evidence.
引用
收藏
页码：622 / 630
页数：9
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