Neuromyelitis optica does not impact periventricular venous density versus healthy controls: a 7.0 Tesla MRI clinical study

被引：12

作者：

Schumacher, Sophie ^{[1
]}

Pache, Florence ^{[1
,3
,4
]}

Bellmann-Strobl, Judith ^{[1
,8
,9
]}

Behrens, Janina ^{[1
]}

Dusek, Petr ^{[2
,3
,4
]}

Harms, Lutz ^{[5
,6
]}

Ruprecht, Klemens ^{[5
,6
]}

Nytrova, Petra ^{[3
,4
]}

Chawla, Sanjeev ^{[10
]}

Niendorf, Thoralf ^{[7
,8
,9
]}

Kister, Ilya ^{[11
]}

Paul, Friedemann ^{[1
,5
,6
,8
,9
]}

Ge, Yulin ^{[10
]}

Wuerfel, Jens ^{[1
,2
,7
,8
,9
,12
]}

Sinnecker, Tim ^{[1
,12
,13
,14
]}

机构：

[1] Charite, NeuroCure Clin Res Ctr, D-13353 Berlin, Germany

[2] Univ Med Gottingen, Inst Neuroradiol, Gottingen, Germany

[3] Charles Univ Prague, Dept Neurol, Gen Univ Hosp Prague, Fac Med 1, Prague, Czech Republic

[4] Charles Univ Prague, Ctr Clin Neurosci, Gen Univ Hosp Prague, Fac Med 1, Prague, Czech Republic

[5] Charite, Clin & Expt Multiple Sclerosis Res Ctr, D-13353 Berlin, Germany

[6] Charite, Dept Neurol, D-13353 Berlin, Germany

[7] Max Delbrck Ctr Mol Med, Berlin Ultrahigh Field Facil, Berlin, Germany

[8] Charite, Expt & Clin Res Ctr, D-13353 Berlin, Germany

[9] Max Delbrck Ctr Mol Med, Berlin, Germany

[10] NYU, Sch Med, Dept Radiol, New York, NY USA

[11] NYU, Dept Neurol, Multiple Sclerosis Care Ctr, Sch Med, New York, NY USA

[12] Med Image Anal Ctr AG MIAC, Basel, Switzerland

[13] Asklepios Fachklinikum Teupitz, Dept Neurol, Teupitz, Germany

[14] Univ Spital Basel, Dept Neurol, Basel, Switzerland

来源：

MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE | 2016年 / 29卷 / 03期

关键词：

Ultrahigh-field MRI; 7T MRI; Multiple sclerosis; Neuromyelitis optica; Venous density; WHITE-MATTER DAMAGE; MULTIPLE-SCLEROSIS; DIFFUSION TENSOR; AQUAPORIN-4; PATTERNS;

D O I：

10.1007/s10334-016-0554-3

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

To quantify the periventricular venous density in neuromyelitis optica spectrum disease (NMOSD) in comparison to that in patients with multiple sclerosis (MS) and healthy control subjects. Sixteen patients with NMOSD, 16 patients with MS and 16 healthy control subjects underwent 7.0-Tesla (7T) MRI. The imaging protocol included T-2*-weighted (T-2*w) fast low angle-shot (FLASH) and fluid-attenuated inversion recovery (FLAIR) sequences. The periventricular venous area (PVA) was manually determined by a blinded investigator in order to estimate the periventricular venous density in a region of interest-based approach. No significant differences in periventricular venous density indicated by PVA were detectable in NMOSD versus healthy controls (p = 0.226). In contrast, PVA was significantly reduced in MS patients compared to healthy controls (p = 0.013). Unlike patients with MS, those suffering from NMOSD did not show reduced venous visibility. This finding may underscore primary and secondary pathophysiological differences between these two distinct diseases of the central nervous system.

引用

页码：535 / 541

页数：7

共 2 条

[1] Neuromyelitis optica does not impact periventricular venous density versus healthy controls: a 7.0 Tesla MRI clinical study
Sophie Schumacher
Florence Pache
Judith Bellmann-Strobl
Janina Behrens
Petr Dusek
Lutz Harms
Klemens Ruprecht
Petra Nytrova
Sanjeev Chawla
Thoralf Niendorf
Ilya Kister
Friedemann Paul
Yulin Ge
Jens Wuerfel
Tim Sinnecker
Magnetic Resonance Materials in Physics, Biology and Medicine, 2016, 29 : 535 - 541
[2] Periventricular venous density in multiple sclerosis is inversely associated with T2 lesion count: a 7 Tesla MRI study
Sinnecker, Tim
Bozin, Ivan
Doerr, Jan
Pfueller, Caspar F.
Harms, Lutz
Niendorf, Thoralf
Brandt, Alexander U.
Paul, Friedemann
Wuerfel, Jens
MULTIPLE SCLEROSIS JOURNAL, 2013, 19 (03) : 316 - 325

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