Enantioselective synthesis of γ-lactones from thioglycolic acid:: Syntheses of (-)-muricatacin and 5-epi-(-)-muricatacin

被引：23

作者：

Chang, SW ^{[1
]}

Hung, CY ^{[1
]}

Liu, HH ^{[1
]}

Uang, BJ ^{[1
]}

机构：

[1] Natl Tsing Hua Univ, Dept Chem, Hsinchu 300, Taiwan

来源：

TETRAHEDRON-ASYMMETRY | 1998年 / 9卷 / 03期

关键词：

D O I：

10.1016/S0957-4166(98)00007-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

An approach for the enantioselective synthesis of functionalized gamma-lactones and its application to the syntheses of (-)-muricatacin 1a and 5-epi-(-)-muricatacin 1b is reported. A sequential oxidation of the intermediate 4 with m-chloroperoxybenzoic acid was conducted to realize the reaction mechanism. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：521 / 529

页数：9

共 22 条

[1]

Burkert U., 1982, Molecular Mechanics

[2]

CHANG YL, 1993, THESIS NATL TSING HU

[3] STEREOSPECIFIC SYNTHESIS OF (+)-MURICATACIN - A BIOLOGICALLY-ACTIVE ACETOGENIN DERIVATIVE [J].