Crosstalk between Oxidative Stress and Ferroptosis/Oxytosis in Ischemic Stroke: Possible Targets and Molecular Mechanisms

被引：138
作者：
Ren, Jia-Xin [1 ,2 ,3 ]
Li, Chao [1 ,2 ,3 ]
Yan, Xiu-Li [1 ,2 ,3 ]
Qu, Yang [1 ,2 ,3 ]
Yang, Yi [1 ,2 ,3 ,4 ]
Guo, Zhen-Ni [1 ,2 ,3 ,4 ]
机构：
[1] Jilin Univ, Hosp 1, Stroke Ctr, 1 Xinmin St, Changchun 130021, Peoples R China
[2] Jilin Univ, Hosp 1, Clin Trial & Res Ctr Stroke, Dept Neurol, 1 Xinmin St, Changchun 130021, Peoples R China
[3] China Natl Comprehens Stroke Ctr, 1 Xinmin St, Changchun 130021, Peoples R China
[4] Jilin Prov Key Lab Cerebrovasc Dis, 1 Xinmin St, Changchun 130021, Peoples R China
来源：
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2021年 / 2021卷
基金：
中国国家自然科学基金;
关键词：
HYDROPEROXIDE GLUTATHIONE-PEROXIDASE; AMINO-ACID-CONCENTRATIONS; TRANSCRIPTION FACTOR NRF2; CELL-DEATH; GLUTAMATE TOXICITY; LIPID-PEROXIDATION; GLYCINE ANTAGONIST; NEURONAL DEATH; IN-VITRO; BRAIN;
D O I：
10.1155/2021/6643382
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Oxidative stress is a key cause of ischemic stroke and an initiator of neuronal dysfunction and death, mainly through the overproduction of peroxides and the depletion of antioxidants. Ferroptosis/oxytosis is a unique, oxidative stress-induced cell death pathway characterized by lipid peroxidation and glutathione depletion. Both oxidative stress and ferroptosis/oxytosis have common molecular pathways. This review summarizes the possible targets and the mechanisms underlying the crosstalk between oxidative stress and ferroptosis/oxytosis in ischemic stroke. This knowledge might help to further understand the pathophysiology of ischemic stroke and open new perspectives for the treatment of ischemic stroke.
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页数：13
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